Peripheral CD4+ T-cell lymphoma

The disease is rare

The patients present superficial lymph node involvement. The cervical areas are predominantly affected, whereas thoracic adenopathies and deep abdominal involvement occur unfrequently at presentation.

The disease cannot be separated from the broad category of peripheral T-cell lymphoma (PTL). PTL is characterized by a heterogeneous cellular composition with small and large cells with an inflammarory background. Lennerts lymphoma can be recognized by the presence of numerous epithelioid histiocytes usually grouped in small clusters. Lennerts lymphoma is not considered as a distinct clinicopathological entity.

The disease must be treated with multiagent chemotherapy and/or radiation therapy as for other PTL

The disease usually runs a relatively aggressive clinical course.

Median survival of 16 to 32 months was reported in some studies