t(1;2)(p22;p12) IGK/BCL10
t(1;14)(p22;q32) IGH/BCL10

2001-01-01   Gianluigi Castoldi  , Antonio Cuneo  

1.Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy

Clinics and Pathology

Disease

the translocation is cytogenetically detectable in a minority of extranodal MALT lymphomas; irrespective of the presence of the 1;14 translocation, mutation or deletion of the BCL10 gene located at 1p22 can be detected by molecular genetic methods in 5-10% of extra-nodal MALT lymphomas, follicle centre cell lymphoma and diffuse large B-cell lymphoma; among MALT lymphoma a preferential association was noted with high-grade histology

Prognosis

in MALT lymphoma there may be an association with aggressive histology and antibiotic-unresponsive forms

Genes Involved and Proteins

Note
the breakpoints on chromosome 1p22 are located upstream of the promoter of the BCL10 gene, which shows inactivating mutations or deletions
Gene name
BCL10 (B-cell CLL/lymphoma 10)
Location
1p22.3
Protein description
322 amino acids; contains a caspase recruitment domain; role in the apoptosis
Gene name
IGH (Immunoglobulin Heavy)
Location
14q32.33

Article Bibliography

Pubmed IDLast YearTitleAuthors
108459242000BCL10 gene mutation in lymphoma.Du MQ et al
99894951999Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types.Willis TG et al
17289481992Cytogenetic study of B-cell lymphoma of mucosa-associated lymphoid tissue.Wotherspoon AC et al
103198631999Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32).Zhang Q et al

Summary

Fusion gene

IGH/BCL10 IGH (14q32.33) BCL10 (1p22.3) M t(14;18)(q32;q21) t(1;14)(p22;q32) t(3;14)(p13;q32)

Fusion gene

IGK/BCL10 IGK (14q32.33) BCL10 (1p22.3) M|IGK/BCL10 IGK (14q32.33) BCL10 (1p22.3) M t(1;2)(p22;p11)
Atlas Image
t(1;14)(p22;q32) - Courtesy Eric Crawford, Genetics Associates, Inc., Nashville, TN 37203, USA

Citation

Gianluigi Castoldi ; Antonio Cuneo

t(1;2)(p22;p12) IGK/BCL10
t(1;14)(p22;q32) IGH/BCL10

Atlas Genet Cytogenet Oncol Haematol. 2001-01-01

Online version: http://atlasgeneticsoncology.org/haematological/2044/css/favicon/js/case-report-explorer/