t(2;2)(p23;q12) GCC2/ALK

0000-00-00   Jean-Loup Huret  , Philippe Dessen  

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

GCC2

Location

2q12.3

Gene name

ALK

Location

2p23.2

Highly cited references

Pubmed IDYearTitleCitations
289705582017Detection of known and novel ALK fusion transcripts in lung cancer patients using next-generation sequencing approaches.41
292902622018GCC2-ALK as a targetable fusion in lung adenocarcinoma and its enduring clinical responses to ALK inhibitors.12
351169682019Rare GCC2-ALK fusion G13:A20 detected by next generation sequencing in non-small cell lung cancer patients and treatment response.1
360037682022Case Report: Efficacy of ensartinib treatment in pulmonary inflammatory myofibroblastic tumor with a rare GCC2-ALK fusion.0

Article Bibliography

Pubmed IDLast YearTitleAuthors
287416622017Molecular breakdown: a comprehensive view of anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer.Noh KW et al

Citation

Jean-Loup Huret ; Philippe Dessen

t(2;2)(p23;q12) GCC2/ALK

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/105216/teaching-explorer/js/_common.js