GCC2 (GRIP and coiled-coil domain containing 2)

2012-11-01 Affiliation

Identity

HGNC

GCC2

LOCATION

2q12.3

LOCUSID

9648

ALIAS

GCC185,RANBP2L4,REN53

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9648
MIM: 612711
HGNC: 23218
Ensembl: ENSG00000135968

Variants:

dbSNP: 9648
ClinVar: 9648
TCGA: ENSG00000135968
COSMIC: GCC2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000135968	ENST00000309863	Q8IWJ2
ENSG00000135968	ENST00000393321	H7BYJ9
ENSG00000135968	ENST00000409821	B8ZZA5
ENSG00000135968	ENST00000409896	B8ZZW2
ENSG00000135968	ENST00000447558	H7C010
ENSG00000135968	ENST00000462897	U3KPU4
ENSG00000135968	ENST00000482325	Q8IWJ2
ENSG00000135968	ENST00000492785	U3KQE0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER traffic	REACTOME	R-HSA-6811442
Retrograde transport at the Trans-Golgi-Network	REACTOME	R-HSA-6811440

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
31840180	2020	Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes.	22
31840180	2020	Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes.	22
27105913	2016	HIV-1 Nef binds with human GCC185 protein and regulates mannose 6 phosphate receptor recycling.	1
27105913	2016	HIV-1 Nef binds with human GCC185 protein and regulates mannose 6 phosphate receptor recycling.	1
26653856	2015	Protein flexibility is required for vesicle tethering at the Golgi.	38
26653856	2015	Protein flexibility is required for vesicle tethering at the Golgi.	38
21875948	2011	GCC185 plays independent roles in Golgi structure maintenance and AP-1-mediated vesicle tethering.	24
22159419	2011	ARL4A acts with GCC185 to modulate Golgi complex organization.	20
21875948	2011	GCC185 plays independent roles in Golgi structure maintenance and AP-1-mediated vesicle tethering.	24
22159419	2011	ARL4A acts with GCC185 to modulate Golgi complex organization.	20
18946081	2009	Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi.	49
19703403	2009	The localization of the Golgin GCC185 is independent of Rab6A/A' and Arl1.	19
18946081	2009	Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi.	49
19703403	2009	The localization of the Golgin GCC185 is independent of Rab6A/A' and Arl1.	19
18243103	2008	Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185.	88

Citation

Dessen P

GCC2 (GRIP and coiled-coil domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/53005/gcc2-(grip-and-coiled-coil-domain-containing-2)