Soft Tissues: Inflammatory myofibroblastic tumor with t(2;17)(p23;q23) CLTC/ALK

2001-08-01   Jean-Loup Huret  

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Clinics

rare soft tissue tumour found in children and young adults

Pathology

spindle cell proliferation with myofibroblastic differenciation and an inflammatory infiltrate

Prognosis

low malignant potential and good prognosis

Genes Involved and Proteins

Gene name

ALK (anaplastic lymphoma receptor tyrosine kinase)

Location

2p23.2

Protein description

1620 amino acids; 177 kDa; glycoprotein (200 kDa mature protein) ; membrane associated tyrosine kinase receptor

Gene name

CLTC (clathrin heavy polypeptide)

Location

17q23.1

Protein description

1675 amino acids, 191 kDa; mediate endocytosis of transmembrane receptors.

Result of the chromosomal anomaly

Description

5 CLTC - 3 ALK

Description

2196 amino acids. 1634 N-term amino acid from CLTC, containing nearly all of CLTC, including the triskelion assembly domain, fused to the 562 C-term amino acids from ALK (i.e. the entire cytoplasmic portion of ALK with the tyrosine kinase domain).

Highly cited references

Pubmed IDYearTitleCitations
121125242002Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor.65
127639272003ALK-positive diffuse large B-cell lymphoma is associated with Clathrin-ALK rearrangements: report of 6 cases.55
127501592003ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma.46
152086562004Differential effects of X-ALK fusion proteins on proliferation, transformation, and invasion properties of NIH3T3 cells.45
211349802011Identification of a novel fusion, SQSTM1-ALK, in ALK-positive large B-cell lymphoma.27
214946212011Inhibition of anaplastic lymphoma kinase (ALK) activity provides a therapeutic approach for CLTC-ALK-positive human diffuse large B cell lymphomas.18
129202292003ALK+, CD30-, CD20- large B-cell lymphoma containing anaplastic lymphoma kinase (ALK) fused to clathrin heavy chain gene (CLTC).18
154929982004ALK-positive diffuse large B-cell lymphoma of the stomach associated with a clathrin-ALK rearrangement.12
235883722013STAT3 pathway is activated in ALK-positive large B-cell lymphoma carrying SQSTM1-ALK rearrangement and provides a possible therapeutic target.10
224744492012Anaplastic lymphoma kinase-positive large B-cell lymphoma: an underrecognized aggressive lymphoma.9
218552322011ALK-positive extramedullary plasmacytoma with expression of the CLTC-ALK fusion transcript.9
158524312006ALK-positive diffuse large B-cell lymphoma.9
241427402014CLTC-ALK fusion as a primary event in congenital blastic plasmacytoid dendritic cell neoplasm.7
245838372014ALK-positive inflammatory myofibroblastic tumor of the abdomen with widespread microscopic multifocality.6
195212802009ALK-positive diffuse large B-cell lymphoma with the t(2;17)(p23;q23).6
159210122005ALK-positive diffuse large B-cell lymphoma: two more cases and a brief literature review.6
347271722022ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition.5
196363982009Anaplastic lymphoma kinase-positive large B-cell lymphoma: a distinct clinicopathological entity.5
184585032008[Cytomorphology and molecular characterization of CLTC-ALK rearrangement in 2 cases of ALK-positive diffuse large B-cell lymphoma with extensive bone marrow involvement].5
340198662021Identification of novel ALK fusions using DNA/RNA sequencing in immunohistochemistry / RT-PCR discordant NSCLC patients.2
324203022020Central nervous system relapse in a pediatric anaplastic large cell lymphoma patient with CLTC/ALK translocation treated with alectinib: A case report.1
351175832020Exome sequencing identified six copy number variations as a prediction model for recurrence of primary prostate cancers with distinctive prognosis.1
127873122003Inflammatory myofibroblastic tumor with predominant anaplastic lymphoma kinase-positive cells lacking a myofibroblastic phenotype.1
351645782022Pediatric Non-Myofibroblastic Primitive Spindle Cell Tumors with ALK Gene Rearrangements and Response to Crizotinib.0
341417902021Diagnosis and treatment of pediatric anaplastic lymphoma kinase-positive large B-cell lymphoma: A case report.0
331543172020Anaplastic Lymphoma Kinase positive large B cell lymphoma of ileocaecal mesentery: A case report.0

Article Bibliography

Pubmed IDLast YearTitleAuthors
114858982001Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor.Bridge JA et al
103831291999Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors.Griffin CA et al
109341372000Aberrant ALK tyrosine kinase signaling. Different cellular lineages, common oncogenic mechanisms.Ladanyi M et al

Citation

Jean-Loup Huret

Soft Tissues: Inflammatory myofibroblastic tumor with t(2;17)(p23;q23) CLTC/ALK

Atlas Genet Cytogenet Oncol Haematol. 2001-08-01

Online version: http://atlasgeneticsoncology.org/solid-tumor/5127/js/lib/gene-explorer/gene-explorer/