A case of pre-B ALL with t(8;14)(q11;q32)

2001-06-01  Gitte Birk Kerndrup, Steen Rosthøj

Institute of Pathology-Chromosome Laboratory, Odense University Hospital, DK-5000 Odense C., Denmark and The Department of Paediatric Oncology, Aalborg Hospital, DK-8000 Aalborg, Denmark

Previous history

Preleukaemia
-
Malignant disease
-
Inborn condition
-

Clinics case report

Age
11 yrs
Sex
M
Liver
+
Spleen
+
Lymph nodes
-
Cns involv
-

Blood data

Wbc
4.3
Hb
3.3
Platelets
16
Blasts
2
Bone marrow
99 blasts

Cyto path

Cytology
ALL-L1
Immunophenotype
CD19+/CD10+/Tdt+
Rearranged ig tcr
IgH: +, TCR: +
Precise diagnosis
pre-B ALL

Survival data

Date diagnosis
08-2000
Complete remission
+
Status
A
Survival
10 +

Karyotype

Sample
Peripheral blood sample
Culture time
24 culture
Banding
G-banding
Results
49,XY,+X,t(8;14)(q11;q32),+12,+21[15]/46,XY[10]

Images

Atlas Image
t(8;14)(q11;q32) G- banding - Gitte Birk Kerndrup, Steen Rosthøj

Comments section

Comments
This case, an eleven year old boy does not have Down syndrome or other inborn genetic conditions. His spleen and liver were remarkably enlarged (spleen: to the umbilical plane, liver: 4 fingers below the costal margin). He had no lymph node involvement, nor CNS- or testis disease. He did not, on flowcytometric immune phenotyping, show evidence of bilineage differentation. The phenotype was the usual for a pre-B ALL (CD10+/CD19+/Tdt+).

Article Bibliography

Pubmed IDLast YearTitleAuthors
106737392000Acute lymphoblastic leukemia with an unusual t(8;14)(q11.2;q32): a Pediatric Oncology Group Study.Kaleem Z et al
109978862000Cytogenetic findings in a population-based series of 787 childhood acute lymphoblastic leukemias from the Nordic countries. The NOPHO Leukemia Cytogenetic Study Group.Forestier E et al

Citation

Gitte Birk Kerndrup, Steen Rosthøj

A case of pre-B ALL with t(8;14)(q11;q32)

Atlas Genet Cytogenet Oncol Haematol. 2001-06-01

Online version: http://atlasgeneticsoncology.org/case-report/208799/a-case-of-pre-b-all-with-t(8