The rare t(4;12)(q11;p13) in an elderly patient with de novo AML with multilineage dysplasia co-expressing stem cell markers
2002-08-01 Sarah Moore, Sanjeev Chunilal, Jacqueline Beerworth Affiliation(1)SA Cancer Cytogenetic Unit, Institute of Medical & veterinary Science, Adelaide, South Australia ; (2)Department of Haematology, The Queen Elizabeth Hospital, Adelaide, South Australia ; e-MAIL [email protected]
Previous history
Preleukaemia
-
Malignant disease
-
Inborn condition
-
Clinics case report
Age
84 yrs
Sex
F
Liver
-
Spleen
-
Lymph nodes
-
Cns involv
-
Blood data
Wbc
30.2
Hb
11.8
Platelets
189
Bone marrow
20
Cyto path
Cytology
(FAB) M2 with maturation; myeloid/stem cell
Immunophenotype
CD13+, CD33+, CD7+, CD34+, CD117+, HLA-DR+
Rearranged ig tcr
-
Pathology
Numerous mononuclear megakaryocytes. Active erythropoiesis. Active granulopoiesis, hypogranular neutrophils, giant band forms, donut nuclei, pseudo Pelger-Huet anomalies. Blasts have moderate nuclear: cytoplasmic ratio.
Precise diagnosis
de novo AML with multilineage dysplasia
Survival data
Date diagnosis
03-2002
Treatment
Palliative treatment with oral etoposide
Complete remission
-
Treatment relat death
-
Status
D
Date last follow
07-2002
Survival
4
Karyotype
Sample
Bone marrow
Culture time
24
Banding
GTL
Results
46,XX,t(4;12)(q11;p13)[15]/46,XX[5]
Images
t(4;12)(q11;p13) GTL banded
Comments section
Comments
This elderly woman did not receive induction chemotherapy. Her disease rapidly progressed from a smouldering leukaemia to a florid form. Findings are consistent with previous reports of t(4;12) with stem cell leukaemia in older patients, and with rarity of additional cytogenetic changes.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 9130613 | 1997 | Characterization of acute leukemia with t(4;12). | Harada H et al |
| 9012712 | 1997 | t(4;12)(q11;p13) in a CD7-negative acute myeloid leukaemia. | Sainty D et al |
| 10477709 | 1999 | Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13). | Cools J et al |
| 10549263 | 1999 | A new translocation, t(2;4;12)(p21;q12;p13), in CD7-positive acute myeloid leukemia: a variant form of t(4;12). | Hamaguchi H et al |
| 11734325 | 2001 | Isochromosome (17)(q10) and translocation (4;12)(q12;p13) in a child with acute myeloid leukemia. | Nathan PC et al |
Citation
Sarah Moore, Sanjeev Chunilal, Jacqueline Beerworth
The rare t(4;12)(q11;p13) in an elderly patient with de novo AML with multilineage dysplasia co-expressing stem cell markers
Atlas Genet Cytogenet Oncol Haematol. 2002-08-01
Online version: http://atlasgeneticsoncology.org/case-report/208803/the-rare-t(4
