A new case of t(1;11)(q21;q23) in a child with M1 ANLL
2005-01-01 Katell Le Du, Eric Jeandidier, Francine Garnache, Pierre Rohrlich, Jean-Luc Bresson, Marie-Agns Collonge-Rame AffiliationService de Génétique, Histologie, Biologie du Développement et de la Reproduction.CHU - Place St Jacques, 25030 BESANCON Cedex, France ; [email protected]
Previous history
Preleukaemia
No preleukemia.
Malignant disease
No previous solid tumors.
Inborn condition
Prematurity (borth at 33 weeks of gestation).
Main items
Acute leukemia in the maternal grand-father
Clinics case report
Age
21 mths
Sex
M
Liver
-
Spleen
-
Lymph nodes
-
Blood data
Wbc
10.6
Hb
7.1
Platelets
71
Blasts
8
Cyto path
Cytology
Bone marrow: 84 % of blastic cells. Cytochemestry: peroxydase: 100% of positive blasts ; butyrate esterase: positive in 11% of blasts.
Immunophenotype
CD13+,CD15+,CD65+,CD33+,CD117+, MPO+, MDR-, CD34-, CD36-, CD14-, CD4+, lineage B-, lineage T-.
Precise diagnosis
AML1 (FAB classification), LAM with 11q23 abnormalities (WHO classification).
Survival data
Date diagnosis
04-2004
Treatment
Induction treatment including cytosine-arabinoside (200 mg/m_ D+1 to D+8) and mitoxantrone (12 mg /m_ D+1, D+2, D+3). One intrathecal injection (including methotrexate, steroids, and cytosine-arabinoside).
Complete remission
Yes
Relapse
-
Survival
8 +
Karyotype
Sample
Bone marrow
Culture time
24/72
Banding
G and R banding
Results
46,XY,t(1;11)(q21;q23)[6]
Mol cytogenet technics
Fluorescence in Situ Hybridization was performed using a MLL dual color, break apart rearrangement probe and a chromosome 1 specific labeled spectrum green painting probe (ABBOTT).
Mol cytogenet results
confirmation of MLL rearrangement by the t(1;11)(q21;q23).
Other molec studies
Results
MLL multiplex PCR [t(4;11), t(6;11), t(9;11), t(10;11), t(11;19)]: negative. ETO/AML1 : negative. MYH11/CBFB : negative. FLT3 mutations research : negative.
Other findings
Note
Meningeal punction : no blastic cells infiltration.
Images
bone marrow (MGG staining)
partial karyotype showing the t(1;11)(q21;q23)(R bands)
FISH results
Comments section
Comments
To our knowledge, 26 cases of translocation t(1;11)(q21;q23) (involved the genes AF1q (1q21) and MLL(11q23) have already been described in the literature. All cases were acute leukemia except for one secondary myelodysplastic syndrome. In 14 cases (57 %), the translocation was the sole abnormality. The other 12 cases showed additional chromosomal abnormalities. This rare translocation is preferentially associated with AML4, AML5, or biphenotypic leukemia of infants or children. Only one case of AML M1/M2 in a 3-year-old female was reported with t(1;11)(q21;q23) as the sole karyotypic change. We present here the second case of AML1 with t(1;11)(q21;q23). The chid is in complete remission at 6 months after diagnosis.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 2702626 | 1989 | Translocation t(1;11)(q21;q23), a new subgroup within M4 acute nonlymphocytic leukemia. | Meloni-Balliet AM et al |
| 7833468 | 1995 | A novel gene, AF1q, fused to MLL in t(1;11) (q21;q23), is specifically expressed in leukemic and immature hematopoietic cells. | Tse W et al |
| 9593286 | 1998 | Ten novel 11q23 chromosomal partner sites. European 11q23 Workshop participants. | Harrison CJ et al |
| 10025907 | 1999 | MLL-AF1q fusion resulting from t(1;11) in acute leukemia. | Busson-Le Coniat M et al |
Citation
Katell Le Du, Eric Jeandidier, Francine Garnache, Pierre Rohrlich, Jean-Luc Bresson, Marie-Agns Collonge-Rame
A new case of t(1;11)(q21;q23) in a child with M1 ANLL
Atlas Genet Cytogenet Oncol Haematol. 2005-01-01
Online version: http://atlasgeneticsoncology.org/case-report/208806/a-new-case-of-t(1
