Translocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders: case 2
2005-01-01 Kavita S Reddy, Kathy Richkind AffiliationGenzyme Genetics, Orange, CA. [email protected]
Previous history
Preleukaemia
Myelofibrosis
Malignant disease
A low-grade lobular and ductal carcinoma with a small percentage of intraductal breast disease treated with tamoxifen.
Clinics case report
Age
61 yrs
Sex
F
Liver
-
Spleen
-
Lymph nodes
-
Cns involv
-
Blood data
Wbc
3.05
Hb
8.1
Platelets
62
Cyto path
Precise diagnosis
Myelofibrosis -> acute leukemia
Survival data
Treatment
Induction treatment: topotecan and cytarabine
Relapse
-
Status
A
Survival
55 +
Karyotype
Sample
PB
Culture time
24/48 unstimulated cultures
Banding
G-banding
Results
46,X,t(X;20)(q13;q13.3),der(1;7)(q10;p10)[20]/46,XX[1]
Images
Fig. 1. Partial karyotypes of the translocation t(X;20)(q13;q13.3) for cases 1ï4 (top to bottom). Arrows indicate the derivatives 20 and X.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 7627939 | 1995 | Biclonal acute monoblastic leukemia showing del(7q) and trisomies 9 and 22. | Wong KF et al |
| 12606138 | 2003 | Translocation (X;20)(q13.1;q13.3) as a primary chromosomal finding in two patients with myelocytic disorders. | Gray BA et al |
| 15676151 | 2005 | Translocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders. | Reddy KS et al |
Citation
Kavita S Reddy, Kathy Richkind
Translocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders: case 2
Atlas Genet Cytogenet Oncol Haematol. 2005-01-01
Online version: http://atlasgeneticsoncology.org/case-report/208808/translocation-(x
