A case of myeloproliferative disorder with t(5;10)(q33;q21.2)
2006-12-01 Valeria AS De Melo, Alistair G Reid AffiliationLeukaemia Cytogenetics Unit, G Block Room G124, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Clinics case report
Age
48 yrs
Sex
M
Spleen
+
Blood data
Wbc
59.1
Hb
11.1
Platelets
58
Blasts
less than 1
Cyto path
Precise diagnosis
Myeloproliferative disorder
Survival data
Date diagnosis
03-1999
Treatment
HU,IS, BMT
Complete remission
+
Treatment relat death
-
Relapse
-
Status
A
Date last follow
05-2005
Survival
75 +
Karyotype
Sample
Bone marrow
Culture time
FUDR
Banding
G-banding
Results
46,XY,t(5;10)(q33;q21.2)[16]/46,XY[8]
Other molec studies
Technics
PCR (Ratio BCR-ABL/ABL)
Results
11-2000: 0; 04-2001: 0; 03-2002: 0.18
Images
Partial karyotype showing the t(5;10)(q33;q21.2) - G-banding
Comments section
Comments
One third of the metaphases examined (8/24) were apparently normal male while the remaining majority of cells showed a balanced translocation between chromosomes 5 and 10. This translocation is poorly known: only 2 cases of atypical chronic myeloid leikemia of unknown prognosis. Further cases will help defining this rare entity.
Bibliography
No bibliography items were found for this article.
Citation
Valeria AS De Melo, Alistair G Reid
A case of myeloproliferative disorder with t(5;10)(q33;q21.2)
Atlas Genet Cytogenet Oncol Haematol. 2006-12-01
Online version: http://atlasgeneticsoncology.org/case-report/208817/a-case-of-myeloproliferative-disorder-with-t(5
