Dic(1;15)(p11;p11) as a non-random abnormality in atypical MPD

2008-05-01  Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne

Laboratoire de Genetique Medicale, Hopital Jeanne de Flandre, CHRU de Lille, France (OT, SR, JLL, CRL); Institut de Recherche sur le Cancer, Centre JP Aubert, Unite Inserm 837, Lille, France (JLL, CRL)

Previous history

Preleukaemia
-
Malignant disease
-
Inborn condition
-

Clinics case report

Age
59 yrs
Sex
F
Liver
-
Spleen
-
Lymph nodes
-
Cns involv
-

Blood data

Wbc
8.5
Hb
19
Platelets
600
Blasts
0

Cyto path

Cytology
-
Immunophenotype
-
Rearranged ig tcr
-
Pathology
MPD
Electron microscopy
-
Precise diagnosis
Atypical myeloproliferative disease, presenting polycythemia and thrombocythemia with myelofibrosis.

Survival data

Date diagnosis
09-1988
Treatment
Hydroxyurea
Complete remission
+
Treatment relat death
-
Relapse
+
Phenotype relapse
AML with unknown phenotype due to bone marrow aspiration failure.
Status
D
Date last follow
12-1997
Survival
111

Karyotype

Sample
bone marrow
Culture time
48
Banding
RHG
Results
47,XX,+9,-15,+dic(1;15)(p11;p11)[20]
Karyotype relapse
47,XX,t(1;6)(q21;q23),+9,-15,+dic(1;15)(p11;p11)[13]
Mol cytogenet technics
NA

Other molec studies

Technics
NA

Images

Atlas Image
Partial karyotype (R-banding) at diagnosis presenting the dic(1;15)(p11;p11) associated with trisomy 9.

Comments section

Comments
This is an additional MPD case presenting this recurrent abnormality, with a 10 years survival. However in this case the death is related to the GVH disease after allograft.

Bibliography

No bibliography items were found for this article.

Citation

Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne

Dic(1;15)(p11;p11) as a non-random abnormality in atypical MPD

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/case-report/208833/dic(1