Dic(1;15)(p11;p11) as a non-random abnormality in essential thrombocytemia

2008-05-01  Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne

Laboratoire de Genetique Medicale, Hopital Jeanne de Flandre, CHRU de Lille, France (OT, SR, JLL, CRL); Institut de Recherche sur le Cancer, Centre JP Aubert, Unite Inserm 837, Lille, France (JLL, CRL)

Previous history

Preleukaemia
-
Malignant disease
-
Inborn condition
-

Clinics case report

Age
74 yrs
Sex
F
Liver
-
Spleen
-
Lymph nodes
-
Cns involv
-

Blood data

Wbc
16.4
Hb
16.3
Platelets
872
Blasts
0

Cyto path

Cytology
-
Immunophenotype
-
Rearranged ig tcr
-
Pathology
MPD
Electron microscopy
-
Precise diagnosis
Essential Thrombocytemia

Survival data

Date diagnosis
03-1997
Treatment
Hydroxyurea
Complete remission
-
Treatment relat death
-
Relapse
-
Status
D
Date last follow
02-2008
Survival
131

Karyotype

Sample
bone marrow
Culture time
48
Banding
GTG
Results
46,XX,[3]/46,XX,-15,+dic(1;15)(p11;p11)[10]
Karyotype relapse
NA
Mol cytogenet technics
NA

Other molec studies

Technics
NA

Other findings

Note
NA

Images

Atlas Image
Karyotype at diagnosis presenting the dic(1;15)(p11;p11) as sole abnormality.

Comments section

Comments
This is an additional MPD case presenting this recurrent abnormality, with 11 years survival. However the death is not related to the disease (cardiac failure) in this case.

Bibliography

No bibliography items were found for this article.

Citation

Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne

Dic(1;15)(p11;p11) as a non-random abnormality in essential thrombocytemia

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/case-report/208834/dic(1