Dic(1;15)(p11;p11) as a non-random abnormality in Myelodysplasic syndrome

2008-05-01  Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne

Laboratoire de Genetique Medicale, Hopital Jeanne de Flandre, CHRU de Lille, France (OT, SR, JLL, CRL); Institut de Recherche sur le Cancer, Centre JP Aubert, Unite Inserm 837, Lille, France (JLL, CRL)

Previous history

Preleukaemia
-
Malignant disease
-
Inborn condition
-

Clinics case report

Age
76
Sex
F
Liver
-
Spleen
-
Lymph nodes
-
Cns involv
-

Blood data

Wbc
6.7
Hb
7.5
Platelets
450
Blasts
0
Bone marrow
52 ringed sideroblast (Perls staining)

Cyto path

Cytology
-
Immunophenotype
-
Rearranged ig tcr
-
Electron microscopy
-
Precise diagnosis
myelodysplastic syndrome (MDS): refractory anemia with ringed sideroblast (RARS)

Survival data

Date diagnosis
05-1994
Treatment
norethandrolone
Complete remission
+
Treatment relat death
-
Relapse
-
Status
D
Date last follow
04-1997
Survival
37

Karyotype

Sample
bone marrow
Culture time
48
Banding
RHG
Results
46,XX,[3]/47,XX,+8[3]/47,XX,+8,-15,+dic(1;15)(p11;p11)[8]
Mol cytogenet technics
NA

Other molec studies

Technics
NA

Other findings

Note
NA

Images

Atlas Image
Partial karyotype at diagnosis presenting the dic(1;15)(p11;p11) associated with trisomy 8.

Comments section

Comments
This is an MDS case presenting this recurrent abnormality, with a 3 years survival. In this case the death is not related to disease (non-small cell lung carcinoma).

Bibliography

No bibliography items were found for this article.

Citation

Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne

Dic(1;15)(p11;p11) as a non-random abnormality in Myelodysplasic syndrome

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/case-report/208835/dic(1