Dic(1;15)(p11;p11) as a non-random abnormality in Myelodysplasic syndrome

Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne Affiliation

Laboratoire de Genetique Medicale, Hopital Jeanne de Flandre, CHRU de Lille, France (OT, SR, JLL, CRL); Institut de Recherche sur le Cancer, Centre JP Aubert, Unite Inserm 837, Lille, France (JLL, CRL)

Previous history

Preleukaemia

Malignant disease

Inborn condition

Clinics case report

Age

Sex

Liver

Spleen

Lymph nodes

Cns involv

Blood data

Wbc

6.7

7.5

Platelets

450

Blasts

Bone marrow

52 ringed sideroblast (Perls staining)

Cyto path

Cytology

Immunophenotype

Rearranged ig tcr

Electron microscopy

Precise diagnosis

myelodysplastic syndrome (MDS): refractory anemia with ringed sideroblast (RARS)

Survival data

Date diagnosis

05-1994

Treatment

norethandrolone

Complete remission

Treatment relat death

Relapse

Status

Date last follow

04-1997

Survival

Karyotype

Sample

bone marrow

Culture time

Banding

RHG

Results

46,XX,[3]/47,XX,+8[3]/47,XX,+8,-15,+dic(1;15)(p11;p11)[8]

Mol cytogenet technics

Other molec studies

Technics

Other findings

Note

Images

Partial karyotype at diagnosis presenting the dic(1;15)(p11;p11) associated with trisomy 8.

Comments section

Comments

This is an MDS case presenting this recurrent abnormality, with a 3 years survival. In this case the death is not related to disease (non-small cell lung carcinoma).

Bibliography

No bibliography items were found for this article.

Citation

Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne

Dic(1;15)(p11;p11) as a non-random abnormality in Myelodysplasic syndrome

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/case-report/208835/haematological-explorer/favicon/welcome