Dic(1;15)(p11;p11) as a non-random abnormality in Polycytemia Vera

2008-05-01  Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne

Laboratoire de Genetique Medicale, Hopital Jeanne de Flandre, CHRU de Lille, France (OT, SR, JLL, CRL); Institut de Recherche sur le Cancer, Centre JP Aubert, Unite Inserm 837, Lille, France (JLL, CRL)

Previous history

Preleukaemia
-
Malignant disease
-
Inborn condition
-

Clinics case report

Age
72 yrs
Sex
F
Liver
-
Spleen
-
Lymph nodes
-
Cns involv
-

Blood data

Wbc
6.5
Hb
19
Platelets
350
Blasts
0

Cyto path

Cytology
-
Immunophenotype
-
Rearranged ig tcr
-
Pathology
MPD, PV
Electron microscopy
-
Precise diagnosis
Polycytemia vera.

Survival data

Date diagnosis
07-1990
Treatment
Hydroxyurea
Complete remission
+
Treatment relat death
-
Relapse
+
Phenotype relapse
AML with unknown phenotype due to bone marrow aspiration failure.
Status
D
Date last follow
09-2001
Survival
134

Karyotype

Sample
bone marrow
Culture time
48
Banding
RHG
Results
46,XX,-15,+dic(1;15)[13]
Karyotype relapse
46,XX,del(7)(q22;q34),-15,+dic(1;15)(p11;p11)[18]
Mol cytogenet technics
NA

Other molec studies

Technics
NA

Images

Atlas Image
Karyotype at diagnosis presenting the isolated dic(1;15)(p11;p11).

Comments section

Comments
This is an additional MPD case presenting this recurrent abnormality, with 11 years survival. However in this case the death is related to disease (respiratory distress on leukostasis).

Bibliography

No bibliography items were found for this article.

Citation

Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne

Dic(1;15)(p11;p11) as a non-random abnormality in Polycytemia Vera

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/case-report/208836/dic(1