t(11;12)(q13;q13) MALAT1::GLI1

Genes involved

MALAT1 (11q13.1)

GLI1 (12q13.3)

Oncogenic mechanisms

overexpression of GLI1 protein

Tumor type

Plexiform fibromyxoma

Gastroblastoma

Highly cited references

Pubmed IDYearTitleCitations
393341522024Gastroblastoma - a case report and literature review.40
371653072023MALAT1 functions as a transcriptional promoter of MALAT1::GLI1 fusion for truncated GLI1 protein expression in cancer.37
313627562019Loss of the PTCH1 tumor suppressor defines a new subset of plexiform fibromyxoma.35
387320672024Plexiform Fibromyxoma in the Stomach: Immunohistochemical Profile and Comprehensive Genetic Characterization.26
361479122022Case Report: Submucosal gastroblastoma with a novel PTCH1::GLI2 gene fusion in a 58-year-old man.26
364213502022Gastroblastoma Treated by Endoscopic Submucosal Excavation with a Novel PTCH1::GLI2 Fusion: A Rare Case Report and Literature Review.22
271010252016Recurrent MALAT1-GLI1 oncogenic fusion and GLI1 up-regulation define a subset of plexiform fibromyxoma.20
293093072018A Distinct Malignant Epithelioid Neoplasm With GLI1 Gene Rearrangements, Frequent S100 Protein Expression, and Metastatic Potential: Expanding the Spectrum of Pathologic Entities With ACTB/MALAT1/PTCH1-GLI1 Fusions.16
368037762023Gastroblastoma mimics the embryonic mesenchyme of the foregut: a case report.13
287310432017Gastroblastoma harbors a recurrent somatic MALAT1-GLI1 fusion gene.0
368237812023Gastroblastoma of the Pylorus: A Case Report and Review of the Literature.0
353973172022Esophageal plexiform fibromyxoma: A case report with molecular analysis for MALAT1-GLI1 fusion.0
319316372020A Malignant Neoplasm From the Jejunum With a MALAT1-GLI1 Fusion and 26-Year Survival History.0
395358502024GLI1, CDK4, and MDM2 Co-Amplification Gastric Plexiform Fibromyxoma: A Case Report and Literature Review.0
340418252021Gastroblastoma with a novel EWSR1-CTBP1 fusion presenting in adolescence.0
382609882024Gastroblastoma with a novel ACTB::GLI1 gene fusion in a 19-year-old male.0
399437272025[Gastric tumors with GLI1 gene alterations (plexiform fibromyxoma and gastroblastoma). Case report and literature review].0

Bibliography

Pubmed IDPublication YearTitleAuthors
271010252016Recurrent MALAT1-GLI1 oncogenic fusion and GLI1 up-regulation define a subset of plexiform fibromyxoma.Spans L, et al
287310432017Gastroblastoma harbors a recurrent somatic MALAT1-GLI1 fusion gene.Graham RP, et al