t(2;5)(q35;q31) FN1::FGF1

Genes involved

FN1 (2q35)

FGF1 (5q31.3)

Oncogenic mechanisms

serve as a ligand activate FGFR1

Tumor type

phosphaturic mesenchymal tumor

Highly cited references

Pubmed IDYearTitleCitations
332096842020Angiogenesis related gene expression significantly associated with the prognostic role of an urothelial bladder carcinoma.37
366868002022Case report: Novel NIPBL-BEND2 fusion gene identified in osteoblastoma-like phosphaturic mesenchymal tumor of the fibula.21
384557092024Phosphaturic mesenchymal tumor with de novo liver metastases: a case report and literature review.17
363272952023Tumor-induced Osteomalacia: A Comprehensive Review.0
274435182016Characterization of FN1-FGFR1 and novel FN1-FGF1 fusion genes in a large series of phosphaturic mesenchymal tumors.0
294460102018Phosphaturic mesenchymal tumors: what an endocrinologist should know.0
317923552020Frequent overexpression of klotho in fusion-negative phosphaturic mesenchymal tumors with tumorigenic implications.0
331514122021Clinicopathologic and molecular features of six cases of phosphaturic mesenchymal tumor.0

Bibliography

Pubmed IDPublication YearTitleAuthors
253198342015Identification of a novel FN1-FGFR1 genetic fusion as a frequent event in phosphaturic mesenchymal tumour.Lee JC, et al
274435182016Characterization of FN1-FGFR1 and novel FN1-FGF1 fusion genes in a large series of phosphaturic mesenchymal tumors.Lee JC, et al