del(4)(p16p16) FGFR3::TACC3

Genes involved

FGFR3 (4p16.3)

TACC3 (4p16.3)

Oncogenic mechanisms

Constitutive activation of FGFR3 tyrosine kinase activity

Targeted therapy

Erdafitinib

Tumor type

Glioblastoma multiforme

Bladder Urothelial Carcinoma

Lung adenocarcinoma

Head and Neck squamous cell carcinoma

Brain Lower Grade Glioma

Highly cited references

Pubmed IDYearTitleCitations
272451472016FGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis (Review).137
381971962023TACC3: a multi-functional protein promoting cancer cell survival and aggressiveness.122
354369522022Imaging diagnosis and treatment selection for brain tumors in the era of molecular therapeutics.113
359558062022FGFR3-TACCs3 Fusions and Their Clinical Relevance in Human Glioblastoma.99
380672582023Diffuse Gliomas with FGFR3-TACC3 Fusions: Oncogenic Mechanisms, Hallmarks, and Therapeutic Perspectives.87
320858052020FGFR- gene family alterations in low-grade neuroepithelial tumors.78
361424172022FGFR1-4 RNA-Based Gene Alteration and Expression Analysis in Squamous Non-Small Cell Lung Cancer.75
379803802023Incidental detection of FGFR3 fusion via liquid biopsy leading to earlier diagnosis of urothelial carcinoma.73
368271142023Stellettin B Induces Cell Death in Bladder Cancer Via Activating the Autophagy/DAPK2/Apoptosis Signaling Cascade.72
361943512023Prevalence of NTRK Fusions in Canadian Solid Tumour Cancer Patients.70
338536732021Novel targetable FGFR2 and FGFR3 alterations in glioblastoma associate with aggressive phenotype and distinct gene expression programs.66
341603642021Insights of fibroblast growth factor receptor 3 aberrations in pan-cancer and their roles in potential clinical treatment.64
293232982018A metabolic function of FGFR3-TACC3 gene fusions in cancer.61
299917992018FGFR3-TACC3 is an oncogenic fusion protein in respiratory epithelium.59
324142132020Novel Gene Fusions in Glioblastoma Tumor Tissue and Matched Patient Plasma.58
360025592022In silico validation of RNA-Seq results can identify gene fusions with oncogenic potential in glioblastoma.56
351518442022HSP90-CDC37 functions as a chaperone for the oncogenic FGFR3-TACC3 fusion.54
292625322017Unique signalling connectivity of FGFR3-TACC3 oncoprotein revealed by quantitative phosphoproteomics and differential network analysis.54
319870432020FGFR3 signaling and function in triple negative breast cancer.54
377202382023Bladder cancer course, four genetic high-risk variants, and histopathological findings.54
388131122024TARGET: A phase I/II open-label multicenter study to assess safety and efficacy of fexagratinib in patients with relapsed/refractory FGFR fusion-positive glioma.52
279306692016Development of RNA-FISH Assay for Detection of Oncogenic FGFR3-TACC3 Fusion Genes in FFPE Samples.50
367763672022Safety and efficacy of the pan-FGFR inhibitor erdafitinib in advanced urothelial carcinoma and other solid tumors: A systematic review and meta-analysis.48
273454132017FGFR3-TACC3 fusion proteins act as naturally occurring drivers of tumor resistance by functionally substituting for EGFR/ERK signaling.47
293586192018Novel therapeutic strategy for cervical cancer harboring FGFR3-TACC3 fusions.46
372102882023Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights.44
331681062020Genetic and epigenetic landscape of IDH-wildtype glioblastomas with FGFR3-TACC3 fusions.44
342471932021Clinicopathological and genomic features in patients with head and neck neuroendocrine carcinoma.44
274098392016FGFR3-TACC3 fusion in solid tumors: mini review.42
387305962024Diffuse Gliomas with FGFR3::TACC3 Fusion: Morphological and Molecular Features and Classification Challenges.42
362167932022Human papillomavirus integration perspective in small cell cervical carcinoma.41
232988362013The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma.41
345224562021Comprehensive identification of FGFR1-4 alterations in 5 557 Chinese patients with solid tumors by next-generation sequencing.41
380746822023Polymorphous low-grade neuroepithelial tumor of the young with FGFR3-TACC3 fusion mimicking high-grade glioma: case report and series of high-grade correlates.40
244768212014Comprehensive molecular characterization of urothelial bladder carcinoma.39
324131192020Clinical, molecular, and radiomic profile of gliomas with FGFR3-TACC3 fusions.39
338980542021FGFR3 overexpression is a useful detection tool for FGFR3 fusions and sequence variations in glioma.39
312906792019Comparative proteogenomic characterization of glioblastoma.38
256090602015Detection, Characterization, and Inhibition of FGFR-TACC Fusions in IDH Wild-type Glioma.38
383122272024Differences in methylation profiles between long-term survivors and short-term survivors of IDH-wild-type glioblastoma.37
352222522022Glioblastoma, IDH-Wild Type With FGFR3-TACC3 Fusion: When Morphology May Reliably Predict the Molecular Profile of a Tumor. A Case Report and Literature Review.36
366470732023Clinico-pathological and epigenetic heterogeneity of diffuse gliomas with FGFR3::TACC3 fusion.36
303449442018Oncogenic driver FGFR3-TACC3 is dependent on membrane trafficking and ERK signaling.36
382552552024Clinicopathological and Molecular Characteristics of IDH-Wildtype Glioblastoma with FGFR3::TACC3 Fusion.36
397177132024CRISPR-Cas13a Targeting the FGFR3-TACC3 Fusion Gene Inhibits Proliferation of Bladder Cancer Cells in vitro and in vivo.36
283794772017Strong FGFR3 staining is a marker for FGFR3 fusions in diffuse gliomas.36
398489782025Cell-free expression and SMA copolymer encapsulation of a functional receptor tyrosine kinase disease variant, FGFR3-TACC3.36
367803302023Oncogenic driver FGFR3-TACC3 requires five coiled-coil heptads for activation and disulfide bond formation for stability.33
288553932017FGFR3-TACC3 cancer gene fusions cause mitotic defects by removal of endogenous TACC3 from the mitotic spindle.33
353440292022Infigratinib in Patients with Recurrent Gliomas and FGFR Alterations: A Multicenter Phase II Study.33
392115182024Durable benefit and slowdown in tumor growth dynamics with erdafitinib in a FGFR3-TACC3 fusion-positive IDH-wild type glioblastoma.33
336044982018Enrichment of FGFR3-TACC3 Fusions in Patients With Bladder Cancer Who Are Young, Asian, or Have Never Smoked.32
342745372021Precise editing of FGFR3-TACC3 fusion genes with CRISPR-Cas13a in glioblastoma.31
300644092018Fibroblast growth factor receptor 3 (FGFR3) aberrations in muscle-invasive urothelial carcinoma.31
340362342021Unraveling Neuroendocrine Gallbladder Cancer: Comprehensive Clinicopathologic and Molecular Characterization.31
255358962014Recurrent FGFR3-TACC3 fusion gene in nasopharyngeal carcinoma.30
384969102024RT-PCR assay to detect FGFR3::TACC3 fusions in formalin-fixed, paraffin-embedded glioblastoma samples.29
228373872012Transforming fusions of FGFR and TACC genes in human glioblastoma.28
332412142020RNAi technology targeting the FGFR3-TACC3 fusion breakpoint: an opportunity for precision medicine.28
289760582018Diffuse gliomas with FGFR3-TACC3 fusion have characteristic histopathological and molecular features.24
355666092022FGFR Fusions as an Acquired Resistance Mechanism Following Treatment with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR TKIs) and a Suggested Novel Target in Advanced Non-Small Cell Lung Cancer (aNSCLC).23
361340172022Extra-CNS and dural metastases in FGFR3::TACC3 fusion+ adult glioblastoma, IDH-wildtype.22
329491762021Targeted Therapy with Anlotinib for a Patient with an Oncogenic FGFR3-TACC3 Fusion and Recurrent Glioblastoma.21
232988392013Multiple functions of a glioblastoma fusion oncogene.21
336044972018Sequential Response to FGFR3 Inhibition With Subsequent Exceptional Response to Atezolizumab in a Patient With FGFR3-TACC3 Fusion-Positive Metastatic Urothelial Carcinoma.16
288384002017Emergence of FGFR3-TACC3 fusions as a potential by-pass resistance mechanism to EGFR tyrosine kinase inhibitors in EGFR mutated NSCLC patients.15
264257232015FGFR3-TACC3: A novel gene fusion in cervical cancer.15
372144142023Successful Treatment and Retreatment With Erdafitinib for a Patient With FGFR3-TACC3 Fusion Squamous NSCLC: A Case Report.10
310360922019Coexisting FGFR3 p.K650T mutation in two FGFR3-TACC3 fusion glioma cases.9
355676062022DNA methylation analysis of glioblastomas harboring FGFR3-TACC3 fusions identifies a methylation subclass with better patient survival.9
350857222022Development of a degrader against oncogenic fusion protein FGFR3-TACC3.0
328549162020Erdafitinib Overcomes FGFR3-TACC3-Mediated Resistance to Osimertinib.0
387017942024Retraction Notice to: Precise editing of FGFR3-TACC3 fusion genes with CRISPR-Cas13a in glioblastoma.0
364552732022Varied histomorphology and clinical outcomes of FGFR3-TACC3 fusion gliomas.0
268692892016Oncogenic Gene Fusion FGFR3-TACC3 Is Regulated by Tyrosine Phosphorylation.0
293302652018FGFR3-TACC3 Activates Mitochondrial Respiration via PIN4 Phosphorylation.0
347665552021Targeting gene fusions in glioma.0
393068892024Pluripotent stem cell-derived CTLs targeting FGFR3-TACC3 fusion gene in osteosarcoma.0
321999322021Absence of FGFR3-TACC3 rearrangement in hematological malignancies with numerical chromosomal alteration.0
393878932024FGFR3::TACC3 fusions in head and neck carcinomas: a study of nine cases highlighting phenotypic heterogeneity, frequent HPV association, and a morphologically distinct subset in favor of a putative entity.0
252949082014Identification of recurrent FGFR3-TACC3 fusion oncogenes from lung adenocarcinoma.0
318103982020Erdafitinib for the treatment of metastatic bladder cancer.0
365300802023Infiltrating gliomas with FGFR alterations: Histologic features, genetic alterations, and potential clinical implications.0
337692732021Can adult IDH-wildtype glioblastomas with FGFR3:TACC3 fusions be reliably predicted by histological features?0
277716112017Identification of a FGFR3-TACC3 fusion in esophageal cancer.0
310788092019Recurrent Papillary Glioneuronal Tumor.0
380840102024Non-Small Cell Lung Carcinoma With Clear Cell Features and FGFR3::TACC3 Gene Rearrangement : Clinicopathologic and Next Generation Sequencing Study of 7 Cases.0
303796402019The role of fibroblast growth factors and their receptors in gliomas: the mutations involved.0
389711172024Novel gene fusions in human oropharyngeal carcinoma.0
322177422020A Highly Potent TACC3 Inhibitor as a Novel Anticancer Drug Candidate.0
353470132022Oncogenic Fusions in Gliomas: An Institutional Experience.0
350661052022Single-cell DNA-seq depicts clonal evolution of multiple driver alterations in osimertinib-resistant patients.0
317352872019Receptor Tyrosine Kinase Fusions as an Actionable Resistance Mechanism to EGFR TKIs in EGFR-Mutant Non-Small-Cell Lung Cancer.0
244523922014A novel somatic FGFR3 mutation in primary lung cancer.0
375841652023Integrated longitudinal circulating tumor DNA profiling predicts immunotherapy response of metastatic urothelial carcinoma in the POLARIS-03 trial.0
391267512024HPV- associated sinonasal squamous cell carcinoma with FGFR3::TACC3 fusion. A rare case report.0
302135232019Molecular Subtypes of Urothelial Bladder Cancer: Results from a Meta-cohort Analysis of 2411 Tumors.0
213805012011Genetic variants in urinary bladder cancer: collective power of the "wimp SNPs".0
346635432022Differences in genomic profile of high-grade urothelial carcinoma according to tumor location.0
319593442020Genome-wide profiling of non-smoking-related lung cancer cells reveals common RB1 rearrangements associated with histopathologic transformation in EGFR-mutant tumors.0

Bibliography

Pubmed IDPublication YearTitleAuthors
303449442018Oncogenic driver FGFR3-TACC3 is dependent on membrane trafficking and ERK signaling.Nelson KN, et al
252949082014Identification of recurrent FGFR3-TACC3 fusion oncogenes from lung adenocarcinoma.Capelletti M, et al
255005442015The landscape and therapeutic relevance of cancer-associated transcript fusions.Yoshihara K, et al