BTG1 (BTG anti-proliferation factor 1)

2003-02-01  

Identity

HGNC
BTG1
LOCATION
12q21.33
LOCUSID
694
ALIAS
APRO2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 694
MIM: 109580
HGNC: 1130
Ensembl: ENSG00000133639

Variants:

dbSNP: 694
ClinVar: 694
TCGA: ENSG00000133639
COSMIC: BTG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133639ENST00000256015P62324
ENSG00000133639ENST00000256015Q6IBC8

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018

References

Pubmed IDYearTitleCitations
147345302004FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1.54
156743372005Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation.23
121355002002Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system.21
203541722010BTG1 regulates glucocorticoid receptor autoinduction in acute lymphoblastic leukemia.19
254059012015B‑cell translocation gene 1 serves as a novel prognostic indicator of hepatocellular carcinoma.18
251151812014Down-regulation of BTG1 by miR-454-3p enhances cellular radiosensitivity in renal carcinoma cells.17
239824702013BTG1 inhibits breast cancer cell growth through induction of cell cycle arrest and apoptosis.15
254871932015Diversity of clinical implication of B-cell translocation gene 1 expression by histopathologic and anatomic subtypes of gastric cancer.14
240847182013BTG1 expression correlates with the pathogenesis and progression of ovarian carcinomas.12
279799242017Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients.12

Citation

Dessen P

BTG1 (BTG anti-proliferation factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/110/btg1-(btg-anti-proliferation-factor-1)