Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Avenue, E1032, Farmington, CT 06030-3101, USA
In Gardner Syndrome, patients may develop the following extra-intestinal manifestations:
In a subset of patients with Turcots syndrome, intestinal polyposis due to APC mutation is associated with brain tumors, especially meduloblastoma.
Generally colon cancers show either chromosomal instability (CIN), which correlates with loss of APC function, or microsatellite instability (MIN), which correlates with loss of mismatch repair function, but not both.
Jennifer S Tirnauer
APC (adenomatous polyposis coli)
Atlas Genet Cytogenet Oncol Haematol. 2005-03-01
Online version: http://atlasgeneticsoncology.org/gene/118/apc-(adenomatous-polyposis-coli)
1998-04-01 APC (adenomatous polyposis coli) by Richard Hamelin