MVP (major vault protein)
2000-05-01 Franck Vigué AffiliationLaboratoire de Cytogenetique - Service dHematologie Biologique, Hopital Hotel-Dieu - 75181 Paris Cedex 04, France
DNA/RNA
Transcription
coding sequence, corresponding to full mRNA, is 2840 bp long
Proteins
Description
110 KD protein, 896 amino acids; major cytoplasmic vault protein; vaults are nucleoproteic complexes composed of the MVP associated with two high-molecular weight proteins p240 and p193 which surround a small 140 nucleotides RNA species
Expression
expressed in a variety of human tumor cell lines, the major part being multidrug resistant; expressed also in primary solid tumors, mainly colon carcinoma or ovarian carcinoma, as well as in hematopoietic cancers (myelodysplastic syndrome, acute myeloid or lymphoid leukemia, multiple myeloma); in normal tissues, LRP expression has a wide distribution, with particularly high levels in epithelial cells of the digestive tract
Localisation
cytoplasmic, in the cytosol, with a little fraction (approximately 5%) located in the nuclear membrane and nuclear pores
Function
vault are cytoplasmic organelles which mediate bidirectional nucleocytoplasmic transport of a wide range of substrates, including cytotoxic drugs; vaults would be involved both in vesicule and cytosolic transport of molecules
Homology
104 kD rat MVP
Implicated in
Entity name
implicated in induced multidrug-resistance to anticancer chemotherapy
Disease
it includes resistance to doxorubicin, vinca alkaloids, mitoxantrone and etoposide; the role of LRP by itself in multidrug-resistance is not completely clear because it is only a part of a nucleo-proteic complex involved in macromolecules transport; the introduction and expression of the LRP gene in cells by transfection does not confer a multidrug-resistance phenotype; overexpression of LRP has been associated with poor response to chemotherapy in various types of leukemia and in ovarian carcinoma, however the role of LRP as pronostic factor remains controversial; in multi-resistant cell lines, LRP amplification within a homogeneous staining region is exceptional
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 10651723 | 2000 | P-glycoprotein and multidrug resistance-associated protein, but not lung resistance protein, lower the intracellular daunorubicin accumulation in acute myeloid leukaemic cells. | Borg AG et al |
| 9713498 | 1998 | Coexpression of multidrug resistance involve proteins: a flow cytometric analysis. | Boutonnat J et al |
| 1360704 | 1992 | Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. | Cole SP et al |
| 9592977 | 1998 | P-glycoprotein (PGP), and not lung resistance-related protein (LRP), is a negative prognostic factor in secondary leukemias. | Damiani D et al |
| 10499614 | 1999 | Expression of the lung resistance protein predicts poor outcome in patients with multiple myeloma. | Filipits M et al |
| 9357965 | 1997 | Expression of the human major vault protein LRP in acute myeloid leukemia. | Hart SM et al |
| 8763338 | 1996 | Major vault protein LRP-related multidrug resistance. | Izquierdo MA et al |
| 9378536 | 1997 | Increased LRP mRNA expression is associated with the MDR phenotype in intrinsically resistant human cancer cell lines. | Laurençot CM et al |
| 9747635 | 1998 | Multidrug resistance in leukemia. | Leith C et al |
| 9643568 | 1998 | Expression of lung resistance protein and correlation with other drug resistance proteins and outcome in myelodysplastic syndromes. | Lepelley P et al |
| 10562814 | 1999 | Increased expression of multidrug resistance related proteins Pgp, MRP1, and LRP/MVP occurs early in colorectal carcinogenesis. | Meijer GA et al |
| 10697509 | 1999 | Expression of the lung resistance protein (LRP) in primary breast cancer. | Pohl G et al |
| 9446666 | 1998 | Lung-resistance-related protein expression is a negative predictive factor for response to conventional low but not to intensified dose alkylating chemotherapy in multiple myeloma. | Raaijmakers HG et al |
| 7671223 | 1995 | The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification. | Slovak ML et al |
| 9713485 | 1998 | Multidrug resistance and its reversal. | Volm M et al |
| 9490695 | 1998 | Relationship between major vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia. | den Boer ML et al |
Other Information
Locus ID:
NCBI: 9961
MIM: 605088
HGNC: 7531
Ensembl: ENSG00000013364
Variants:
dbSNP: 9961
ClinVar: 9961
TCGA: ENSG00000013364
COSMIC: MVP
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Innate Immune System | REACTOME | R-HSA-168249 |
| Neutrophil degranulation | REACTOME | R-HSA-6798695 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38264642 | 2023 | Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6. | 1 |
| 38264642 | 2023 | Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6. | 1 |
| 32894437 | 2021 | Y-box binding protein 1 (YB-1) promotes gefitinib resistance in lung adenocarcinoma cells by activating AKT signaling and epithelial-mesenchymal transition through targeting major vault protein (MVP). | 7 |
| 33609362 | 2021 | Proteomic analyses identify major vault protein as a prognostic biomarker for fatal prostate cancer. | 9 |
| 33637972 | 2021 | Constitutive GLI1 expression in chondrosarcoma is regulated by major vault protein via mTOR/S6K1 signaling cascade. | 10 |
| 34829999 | 2021 | MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer Cells. | 4 |
| 32894437 | 2021 | Y-box binding protein 1 (YB-1) promotes gefitinib resistance in lung adenocarcinoma cells by activating AKT signaling and epithelial-mesenchymal transition through targeting major vault protein (MVP). | 7 |
| 33609362 | 2021 | Proteomic analyses identify major vault protein as a prognostic biomarker for fatal prostate cancer. | 9 |
| 33637972 | 2021 | Constitutive GLI1 expression in chondrosarcoma is regulated by major vault protein via mTOR/S6K1 signaling cascade. | 10 |
| 34829999 | 2021 | MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer Cells. | 4 |
| 30082909 | 2019 | Immunoregulatory protein B7-H3 regulates cancer stem cell enrichment and drug resistance through MVP-mediated MEK activation. | 45 |
| 30336197 | 2019 | Major vault protein is a direct target of Notch1 signaling and contributes to chemoresistance in triple-negative breast cancer cells. | 30 |
| 30654824 | 2019 | Adipocytes promote breast cancer resistance to chemotherapy, a process amplified by obesity: role of the major vault protein (MVP). | 59 |
| 30674943 | 2019 | Lung resistance-related protein (LRP) predicts favorable therapeutic outcome in Acute Myeloid Leukemia. | 4 |
| 30996248 | 2019 | Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK-NF-κB signaling mediated inflammation. | 42 |
Citation
Franck Vigué
MVP (major vault protein)
Atlas Genet Cytogenet Oncol Haematol. 2000-05-01
Online version: http://atlasgeneticsoncology.org/gene/120/mvp-(major-vault-protein)
