NCOA2 (nuclear receptor coactivator 2)

2003-05-01  

Identity

HGNC
LOCATION
8q13.3
LOCUSID
ALIAS
GRIP1,KAT13C,NCoA-2,SRC2,TIF2,bHLHe75
FUSION GENES

Other Information

Locus ID:

NCBI: 10499
MIM: 601993
HGNC: 7669
Ensembl: ENSG00000140396

Variants:

dbSNP: 10499
ClinVar: 10499
TCGA: ENSG00000140396
COSMIC: NCOA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140396ENST00000452400Q15596
ENSG00000140396ENST00000518287E7EWM1
ENSG00000140396ENST00000518363H0YBB6
ENSG00000140396ENST00000519724E5RFN9
ENSG00000140396ENST00000520416A0A1D5RMT0

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Thyroid hormone signaling pathwayKEGGhsa04919
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Mitochondrial biogenesisREACTOMER-HSA-1592230
Transcriptional activation of mitochondrial biogenesisREACTOMER-HSA-2151201
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate PKNsREACTOMER-HSA-5625740
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3REACTOMER-HSA-5625886
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
YAP1- and WWTR1 (TAZ)-stimulated gene expressionREACTOMER-HSA-2032785
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108
RORA activates gene expressionREACTOMER-HSA-1368082
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Regulation of cholesterol biosynthesis by SREBP (SREBF)REACTOMER-HSA-1655829
Activation of gene expression by SREBF (SREBP)REACTOMER-HSA-2426168
Bile acid and bile salt metabolismREACTOMER-HSA-194068
Synthesis of bile acids and bile saltsREACTOMER-HSA-192105
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterolREACTOMER-HSA-193368
Synthesis of bile acids and bile salts via 27-hydroxycholesterolREACTOMER-HSA-193807
Recycling of bile acids and saltsREACTOMER-HSA-159418
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
Endogenous sterolsREACTOMER-HSA-211976
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447199Bipolar DisorderDiseaseLiterature, MultilinkAnnotationassociated24718920

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
124810242002Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts.82
192550642009Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk.70
126822922003Filamin-A fragment localizes to the nucleus to regulate androgen receptor and coactivator functions.69
146627702004Epidermal growth factor increases coactivation of the androgen receptor in recurrent prostate cancer.65
126765842003MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
220341772012Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data.52
120606662002The nuclear receptor interaction domain of GRIP1 is modulated by covalent attachment of SUMO-1.45
119375042002Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor alpha.41

Citation

Dessen P

NCOA2 (nuclear receptor coactivator 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/141/ncoa2-(nuclear-receptor-coactivator-2)