RBM15 (RNA binding motif protein 15)

2001-06-01   Jean-Loup Huret  

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
RBM15
LOCATION
1p13.3
IMAGE
Atlas Image
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
64783
ALIAS
OTT,OTT1,SPEN
FUSION GENES
Show Gene Fusions

DNA/RNA

Description

one exon

Transcription

alternate splicing; a 8.2 kb single exon transcript and a 3.9 kb transcript

Proteins

Description

957 amino acids; contains 3 RNA recognition motif (RMM) consensus in NH2 term and up to amino acid 528, and a SPOC (Spen Paralog and Ortholog) domain in COOH-term

Expression

wide

Homology

with the Drosophila split-end (spen)

Implicated in

Entity name
t(1;22)(p13;q13) / acute megakaryocytic leukaemia (M7 AML) --> RBM15 - MAL
Disease
acute megakaryocytic leukaemia found in infants
Prognosis
complete remission in only 50% of cases; median survival: 8 months
Cytogenetics
60% of cases have the t(1;22) as a single anomaly; the remaining cases exhibit complex and hyperploid clones
Hybrid gene
5 OTT - 3 MAL, comprisng most of OTT fused to most of MAL; the reciprocal 5 MAL - 3 OTT may or may not be present
Fusion protein
includes most of OTT with the RNA recognition motifs and the SPOC domain in N-term, and most of MAL, with the scaffold attachment factor box in C-term
Oncogenesis
may play a role in chromatin organization, HOX differentiation pathways, or extracellular signaling

Article Bibliography

Pubmed IDLast YearTitleAuthors
113443112001Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia.Mercher T et al

Other Information

Locus ID:

NCBI: 64783
MIM: 606077
HGNC: 14959
Ensembl: ENSG00000162775

Variants:

dbSNP: 64783
ClinVar: 64783
TCGA: ENSG00000162775
COSMIC: RBM15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162775ENST00000369784Q96T37
ENSG00000162775ENST00000487146Q96T37
ENSG00000162775ENST00000487146A0A499FJY3
ENSG00000162775ENST00000602849Q96T37
ENSG00000162775ENST00000617047A0A087WWP4
ENSG00000162775ENST00000618772Q96T37
ENSG00000162775ENST00000650953A0A494C001
ENSG00000162775ENST00000652342Q96T37
ENSG00000162775ENST00000652747Q96T37
ENSG00000162775ENST00000654015A0A499FJY3

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
388422012024RBM15-Mediated N6-Methyl Adenosine (m6A) Modification of EZH2 Drives the Epithelial-Mesenchymal Transition of Cervical Cancer.0
388422012024RBM15-Mediated N6-Methyl Adenosine (m6A) Modification of EZH2 Drives the Epithelial-Mesenchymal Transition of Cervical Cancer.0
367151152023RBM15 silencing promotes ferroptosis by regulating the TGF-β/Smad2 pathway in lung cancer.5
373347622023RBM15 m(6) A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling.2
374716372023Regulatory mechanism of RNA binding motif protein 15-mediated N(6) methyladenosine modification in proliferation, invasion, and migration of colorectal cancer cells.2
374749262023Knockdown of RBM15 inhibits tumor progression and the JAK-STAT signaling pathway in cervical cancer.2
375941262023RBM15‑mediating MDR1 mRNA m(6)A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer.5
367151152023RBM15 silencing promotes ferroptosis by regulating the TGF-β/Smad2 pathway in lung cancer.5
373347622023RBM15 m(6) A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling.2
374716372023Regulatory mechanism of RNA binding motif protein 15-mediated N(6) methyladenosine modification in proliferation, invasion, and migration of colorectal cancer cells.2
374749262023Knockdown of RBM15 inhibits tumor progression and the JAK-STAT signaling pathway in cervical cancer.2
375941262023RBM15‑mediating MDR1 mRNA m(6)A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer.5
348424572022Knockdown RBM15 Inhibits Colorectal Cancer Cell Proliferation and Metastasis Via N6-Methyladenosine (m6A) Modification of MyD88 mRNA.13
353813262022Epigenetic activation of RBM15 promotes clear cell renal cell carcinoma growth, metastasis and macrophage infiltration by regulating the m6A modification of CXCL11.17
358093192022The prognostic value of N6-methyladenosine RBM15 regulators in lung adenocarcinoma.7

Citation

Jean-Loup Huret

RBM15 (RNA binding motif protein 15)

Atlas Genet Cytogenet Oncol Haematol. 2001-06-01

Online version: http://atlasgeneticsoncology.org/gene/175/rbm15-(rna-binding-motif-protein-15)