RBM15 (RNA binding motif protein 15)
2001-06-01 Jean-Loup Huret AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Identity
HGNC
LOCATION
1p13.3
IMAGE
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
OTT,OTT1,SPEN
FUSION GENES
DNA/RNA
Description
one exon
Transcription
alternate splicing; a 8.2 kb single exon transcript and a 3.9 kb transcript
Proteins
Description
957 amino acids; contains 3 RNA recognition motif (RMM) consensus in NH2 term and up to amino acid 528, and a SPOC (Spen Paralog and Ortholog) domain in COOH-term
Expression
wide
Homology
with the Drosophila split-end (spen)
Implicated in
Entity name
Disease
acute megakaryocytic leukaemia found in infants
Prognosis
complete remission in only 50% of cases; median survival: 8 months
Cytogenetics
60% of cases have the t(1;22) as a single anomaly; the remaining cases exhibit complex and hyperploid clones
Hybrid gene
5 OTT - 3 MAL, comprisng most of OTT fused to most of MAL; the reciprocal 5 MAL - 3 OTT may or may not be present
Fusion protein
includes most of OTT with the RNA recognition motifs and the SPOC domain in N-term, and most of MAL, with the scaffold attachment factor box in C-term
Oncogenesis
may play a role in chromatin organization, HOX differentiation pathways, or extracellular signaling
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 11344311 | 2001 | Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. | Mercher T et al |
Other Information
Locus ID:
NCBI: 64783
MIM: 606077
HGNC: 14959
Ensembl: ENSG00000162775
Variants:
dbSNP: 64783
ClinVar: 64783
TCGA: ENSG00000162775
COSMIC: RBM15
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38842201 | 2024 | RBM15-Mediated N6-Methyl Adenosine (m6A) Modification of EZH2 Drives the Epithelial-Mesenchymal Transition of Cervical Cancer. | 0 |
| 38842201 | 2024 | RBM15-Mediated N6-Methyl Adenosine (m6A) Modification of EZH2 Drives the Epithelial-Mesenchymal Transition of Cervical Cancer. | 0 |
| 36715115 | 2023 | RBM15 silencing promotes ferroptosis by regulating the TGF-β/Smad2 pathway in lung cancer. | 5 |
| 37334762 | 2023 | RBM15 m(6) A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling. | 2 |
| 37471637 | 2023 | Regulatory mechanism of RNA binding motif protein 15-mediated N(6) methyladenosine modification in proliferation, invasion, and migration of colorectal cancer cells. | 2 |
| 37474926 | 2023 | Knockdown of RBM15 inhibits tumor progression and the JAK-STAT signaling pathway in cervical cancer. | 2 |
| 37594126 | 2023 | RBM15‑mediating MDR1 mRNA m(6)A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer. | 5 |
| 36715115 | 2023 | RBM15 silencing promotes ferroptosis by regulating the TGF-β/Smad2 pathway in lung cancer. | 5 |
| 37334762 | 2023 | RBM15 m(6) A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling. | 2 |
| 37471637 | 2023 | Regulatory mechanism of RNA binding motif protein 15-mediated N(6) methyladenosine modification in proliferation, invasion, and migration of colorectal cancer cells. | 2 |
| 37474926 | 2023 | Knockdown of RBM15 inhibits tumor progression and the JAK-STAT signaling pathway in cervical cancer. | 2 |
| 37594126 | 2023 | RBM15‑mediating MDR1 mRNA m(6)A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer. | 5 |
| 34842457 | 2022 | Knockdown RBM15 Inhibits Colorectal Cancer Cell Proliferation and Metastasis Via N6-Methyladenosine (m6A) Modification of MyD88 mRNA. | 13 |
| 35381326 | 2022 | Epigenetic activation of RBM15 promotes clear cell renal cell carcinoma growth, metastasis and macrophage infiltration by regulating the m6A modification of CXCL11. | 17 |
| 35809319 | 2022 | The prognostic value of N6-methyladenosine RBM15 regulators in lung adenocarcinoma. | 7 |
Citation
Jean-Loup Huret
RBM15 (RNA binding motif protein 15)
Atlas Genet Cytogenet Oncol Haematol. 2001-06-01
Online version: http://atlasgeneticsoncology.org/gene/175/rbm15-(rna-binding-motif-protein-15)
