MLF1 (myelodysplasia/myeloid leukemia factor 1)
1997-12-01 Jean-Loup Huret AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
DNA/RNA
Transcription
alternate splicing: 1.4 and 2.4 kb
Proteins
Description
267 amino acids; 31 KDa; do not contain known functional motifs
Expression
MLF1 transcripts widely expressed (gonads, muscle, heart,
kidney, colon)
Localisation
cytoplasmic localisation
Homology
none is known, apart from MLF2 (40% homology)
Implicated in
Entity name
t(3;5)(q25;q34)/AML or MDS--> NPM1 - MLF1
Disease
AML, MDS, BC-CML; trilineage involvement
Prognosis
very poor
Cytogenetics
location of breakpoints difficult to ascertain
Hybrid gene
5 NPM1-3 MLF1 on der(5)
Fusion protein
nuclear protein
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 8570204 | 1996 | The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1. | Yoneda-Kato N et al |
Other Information
Locus ID:
NCBI: 4291
MIM: 601402
HGNC: 7125
Ensembl: ENSG00000178053
Variants:
dbSNP: 4291
ClinVar: 4291
TCGA: ENSG00000178053
COSMIC: MLF1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Transcriptional misregulation in cancer | KEGG | ko05202 |
| Transcriptional misregulation in cancer | KEGG | hsa05202 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37486965 | 2023 | Epigenetic deregulation of MLF1 drives intrahepatic cholangiocarcinoma progression through EGFR/AKT and Wnt/β-catenin signaling. | 3 |
| 37486965 | 2023 | Epigenetic deregulation of MLF1 drives intrahepatic cholangiocarcinoma progression through EGFR/AKT and Wnt/β-catenin signaling. | 3 |
| 32703400 | 2020 | CRL4(DCAF8) and USP11 oppositely regulate the stability of myeloid leukemia factors (MLFs). | 4 |
| 32703400 | 2020 | CRL4(DCAF8) and USP11 oppositely regulate the stability of myeloid leukemia factors (MLFs). | 4 |
| 31675375 | 2019 | NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes. | 5 |
| 31675375 | 2019 | NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes. | 5 |
| 27840155 | 2017 | Modulation of mutant Huntingtin aggregates and toxicity by human myeloid leukemia factors. | 8 |
| 27984043 | 2017 | Myeloid Leukemia Factor Acts in a Chaperone Complex to Regulate Transcription Factor Stability and Gene Expression. | 6 |
| 28137643 | 2017 | MLF1 is a proapoptotic antagonist of HOP complex-mediated survival. | 3 |
| 28545128 | 2017 | Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma. | 50 |
| 27840155 | 2017 | Modulation of mutant Huntingtin aggregates and toxicity by human myeloid leukemia factors. | 8 |
| 27984043 | 2017 | Myeloid Leukemia Factor Acts in a Chaperone Complex to Regulate Transcription Factor Stability and Gene Expression. | 6 |
| 28137643 | 2017 | MLF1 is a proapoptotic antagonist of HOP complex-mediated survival. | 3 |
| 28545128 | 2017 | Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma. | 50 |
| 23271436 | 2013 | Subcellular localization of full-length human myeloid leukemia factor 1 (MLF1) is independent of 14-3-3 proteins. | 2 |
Citation
Jean-Loup Huret
MLF1 (myelodysplasia/myeloid leukemia factor 1)
Atlas Genet Cytogenet Oncol Haematol. 1997-12-01
Online version: http://atlasgeneticsoncology.org/gene/18/cancer-prone-explorer/gene-explorer/submit-meetings/
