TP53BP1 (tumor protein p53 binding protein 1)

2003-02-01  

Identity

HGNC
TP53BP1
LOCATION
15q15.3
LOCUSID
7158
ALIAS
53BP1,TDRD30,p202,p53BP1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7158
MIM: 605230
HGNC: 11999
Ensembl: ENSG00000067369

Variants:

dbSNP: 7158
ClinVar: 7158
TCGA: ENSG00000067369
COSMIC: TP53BP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000067369ENST00000263801Q12888
ENSG00000067369ENST00000382039A6NNK5
ENSG00000067369ENST00000382044Q12888
ENSG00000067369ENST00000411772H7C3N7
ENSG00000067369ENST00000413546C9JXV0
ENSG00000067369ENST00000417342H7C151
ENSG00000067369ENST00000434561H7BZY0
ENSG00000067369ENST00000434595H7C495
ENSG00000067369ENST00000450115Q12888
ENSG00000067369ENST00000467474M0R142

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
DNA Double Strand Break ResponseREACTOMER-HSA-5693606
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksREACTOMER-HSA-5693565
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
Nonhomologous End-Joining (NHEJ)REACTOMER-HSA-5693571
SUMOylation of transcription factorsREACTOMER-HSA-3232118

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381730162024Extracellular vesicle-derived TP53BP1, CD34, and PBX1 from human peripheral blood serve as potential biomarkers for the assessment and prediction of vascular aging.0
382279442024The dimeric deubiquitinase USP28 integrates 53BP1 and MYC functions to limit DNA damage.0
382449282024Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer.4
385472922024Control of cell proliferation by memories of mitosis.2
385542792024BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks.0
388219842024Evolved histone tail regulates 53BP1 recruitment at damaged chromatin.0
381730162024Extracellular vesicle-derived TP53BP1, CD34, and PBX1 from human peripheral blood serve as potential biomarkers for the assessment and prediction of vascular aging.0
382279442024The dimeric deubiquitinase USP28 integrates 53BP1 and MYC functions to limit DNA damage.0
382449282024Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer.4
385472922024Control of cell proliferation by memories of mitosis.2
385542792024BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks.0
388219842024Evolved histone tail regulates 53BP1 recruitment at damaged chromatin.0
366064872023Incorporation of 53BP1 into phase-separated bodies in cancer cells during aberrant mitosis.0
366428152023DNA damage-induced cellular senescence is regulated by 53BP1 accumulation in the nuclear foci and phase separation.5
367948492023HDGFRP3 interaction with 53BP1 promotes DNA double-strand break repair.5

Citation

Dessen P

TP53BP1 (tumor protein p53 binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/189/tp53bp1-(tumor-protein-p53-binding-protein-1)