Identity
HGNC
LOCATION
16q24.3
LOCUSID
ALIAS
CMM5,MSH-R,SHEP2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4157
MIM: 155555
HGNC: 6929
Ensembl: ENSG00000258839
Variants:
dbSNP: 4157
ClinVar: 4157
TCGA: ENSG00000258839
COSMIC: MC1R
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447321 | Depressive Disorder, Major | Disease | ClinicalAnnotation | associated | PD | 21052032 | |
| PA449233 | desipramine | Chemical | ClinicalAnnotation | associated | PD | 21052032 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38565069 | 2024 | Melanoma-associated melanocortin 1 receptor variants confer redox signaling-dependent protection against oxidative DNA damage. | 0 |
| 38565069 | 2024 | Melanoma-associated melanocortin 1 receptor variants confer redox signaling-dependent protection against oxidative DNA damage. | 0 |
| 36602233 | 2023 | Melanocortin 1 receptor variants and their association with phenotypic characteristics and sporadic multiple primary melanomas in a cohort of 402 Spanish subjects. | 0 |
| 36701140 | 2023 | AMPK Phosphorylates ZDHHC13 to Increase MC1R Activity and Suppress Melanomagenesis. | 4 |
| 36879448 | 2023 | The MC1R r allele does not increase melanoma risk in MITF E318K carriers. | 0 |
| 37569558 | 2023 | Melanocortin 1 Receptor (MC1R): Pharmacological and Therapeutic Aspects. | 3 |
| 37608347 | 2023 | Alpha-melanocyte stimulating hormone (α-MSH): biology, clinical relevance and implication in melanoma. | 4 |
| 37714844 | 2023 | Activation of melanocortin-1 receptor signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity. | 2 |
| 37762683 | 2023 | A Side-by-Side Comparison of Wildtype and Variant Melanocortin 1 Receptor Signaling with Emphasis on Protection against Oxidative Damage to DNA. | 2 |
| 36602233 | 2023 | Melanocortin 1 receptor variants and their association with phenotypic characteristics and sporadic multiple primary melanomas in a cohort of 402 Spanish subjects. | 0 |
| 36701140 | 2023 | AMPK Phosphorylates ZDHHC13 to Increase MC1R Activity and Suppress Melanomagenesis. | 4 |
| 36879448 | 2023 | The MC1R r allele does not increase melanoma risk in MITF E318K carriers. | 0 |
| 37569558 | 2023 | Melanocortin 1 Receptor (MC1R): Pharmacological and Therapeutic Aspects. | 3 |
| 37608347 | 2023 | Alpha-melanocyte stimulating hormone (α-MSH): biology, clinical relevance and implication in melanoma. | 4 |
| 37714844 | 2023 | Activation of melanocortin-1 receptor signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity. | 2 |
Citation
Dessen P
MC1R (melanocortin 1 receptor)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/191/mc1r-(melanocortin-1-receptor)
