CHEK1 (checkpoint kinase 1)

2003-02-01   Dessen P  

Identity

HGNC
CHEK1
LOCATION
11q24.2
LOCUSID
1111
ALIAS
CHK1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1111
MIM: 603078
HGNC: 1925
Ensembl: ENSG00000149554

Variants:

dbSNP: 1111
ClinVar: 1111
TCGA: ENSG00000149554
COSMIC: CHEK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149554ENST00000278916O14757
ENSG00000149554ENST00000278916J3KN87
ENSG00000149554ENST00000427383E7EPP6
ENSG00000149554ENST00000428830O14757
ENSG00000149554ENST00000438015O14757
ENSG00000149554ENST00000524737O14757
ENSG00000149554ENST00000525396E9PRU7
ENSG00000149554ENST00000526937E9PJI4
ENSG00000149554ENST00000527013E9PKQ3
ENSG00000149554ENST00000531607A0A087WT52
ENSG00000149554ENST00000532449O14757
ENSG00000149554ENST00000532669E9PPA5
ENSG00000149554ENST00000534070O14757
ENSG00000149554ENST00000534685E9PQW7
ENSG00000149554ENST00000544373O14757

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
p53 signaling pathwayKEGGko04115
Cell cycleKEGGhsa04110
p53 signaling pathwayKEGGhsa04115
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
DNA damage-induced cell cycle checkpointsKEGGhsa_M00691
DNA damage-induced cell cycle checkpointsKEGGM00691
Signal TransductionREACTOMER-HSA-162582
Signaling by SCF-KITREACTOMER-HSA-1433557
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G1/S DNA Damage CheckpointsREACTOMER-HSA-69615
p53-Independent G1/S DNA damage checkpointREACTOMER-HSA-69613
p53-Independent DNA Damage ResponseREACTOMER-HSA-69610
Ubiquitin Mediated Degradation of Phosphorylated Cdc25AREACTOMER-HSA-69601
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexREACTOMER-HSA-75035
Activation of ATR in response to replication stressREACTOMER-HSA-176187
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Homologous DNA Pairing and Strand ExchangeREACTOMER-HSA-5693579
Presynaptic phase of homologous DNA pairing and strand exchangeREACTOMER-HSA-5693616
TP53 Regulates Transcription of DNA Repair GenesREACTOMER-HSA-6796648
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA61ATMGenePathwayassociated
PA74ATRGenePathwayassociated
PA95CCNB1GenePathwayassociated

References

Pubmed IDYearTitleCitations
380474732024In silico and structure-based evaluation of deleterious mutations identified in human Chk1, Chk2, and Wee1 protein kinase.0
382667822024OTUB1 Targets CHK1 for Deubiquitination and Stabilization to Facilitate Lung Cancer Progression and Radioresistance.0
385788302024Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates.0
385888042024The luciferase-based in vivo protein-protein interaction assay revealed that CHK1 promotes PP2A and PME-1 interaction.0
380474732024In silico and structure-based evaluation of deleterious mutations identified in human Chk1, Chk2, and Wee1 protein kinase.0
382667822024OTUB1 Targets CHK1 for Deubiquitination and Stabilization to Facilitate Lung Cancer Progression and Radioresistance.0
385788302024Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates.0
385888042024The luciferase-based in vivo protein-protein interaction assay revealed that CHK1 promotes PP2A and PME-1 interaction.0
352311582023When more is less: heritable gain-of-function chk1 mutations impair human fertility.4
366715102023Claspin-Dependent and -Independent Chk1 Activation by a Panel of Biological Stresses.1
369191242023The Prevalence of CHEK1 and CHEK2 Mutations in Prostate Cancer: a Retrospective Cohort Study.1
373930212023Combined Aurora Kinase A and CHK1 Inhibition Enhances Radiosensitivity of Triple-Negative Breast Cancer Through Induction of Apoptosis and Mitotic Catastrophe Associated With Excessive DNA Damage.1
377153822023Bioinformatic analysis of CHEK1 as a marker of glomerular epithelial cell injury in diabetic nephropathy.0
377622282023Long Noncoding RNA ZBED5-AS1 Facilitates Tumor Progression and Metastasis in Lung Adenocarcinoma via ZNF146/ATR/Chk1 Axis.1
377731762023Mild replication stress causes premature centriole disengagement via a sub-critical Plk1 activity under the control of ATR-Chk1.0

Citation

Dessen P

CHEK1 (checkpoint kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/210/chek1-(checkpoint-kinase-1)