MXD1 (MAX dimerization protein 1)

2003-02-01 Affiliation

Identity

HGNC

MXD1

LOCATION

2p13.3

LOCUSID

4084

ALIAS

BHLHC58,MAD,MAD1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4084
MIM: 600021
HGNC: 6761
Ensembl: ENSG00000059728

Variants:

dbSNP: 4084
ClinVar: 4084
TCGA: ENSG00000059728
COSMIC: MXD1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000059728	ENST00000264444	Q05195
ENSG00000059728	ENST00000409442	F8WBI0
ENSG00000059728	ENST00000435990	C9JBE8
ENSG00000059728	ENST00000540449	Q05195

Expression (GTEx)

100

150

200

250

300

350

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
33537096	2021	Targeting miR-21 with NL101 blocks c-Myc/Mxd1 loop and inhibits the growth of B cell lymphoma.	7
34761715	2021	MXD1 is a Potential Prognostic Biomarker and Correlated With Specific Molecular Change and Tumor Microenvironment Feature in Esophageal Squamous Cell Carcinoma.	2
33537096	2021	Targeting miR-21 with NL101 blocks c-Myc/Mxd1 loop and inhibits the growth of B cell lymphoma.	7
34761715	2021	MXD1 is a Potential Prognostic Biomarker and Correlated With Specific Molecular Change and Tumor Microenvironment Feature in Esophageal Squamous Cell Carcinoma.	2
31635836	2020	The MicroRNA-382-5p/MXD1 Axis Relates to Breast Cancer Progression and Promotes Cell Malignant Phenotypes.	6
32794336	2020	MXD1 regulates the H9N2 and H1N1 influenza A virus-induced chemokine expression and their replications in human macrophage.	3
31635836	2020	The MicroRNA-382-5p/MXD1 Axis Relates to Breast Cancer Progression and Promotes Cell Malignant Phenotypes.	6
32794336	2020	MXD1 regulates the H9N2 and H1N1 influenza A virus-induced chemokine expression and their replications in human macrophage.	3
30419548	2018	MXD1 regulates the imatinib resistance of chronic myeloid leukemia cells by repressing BCR-ABL1 expression.	0
30419548	2018	MXD1 regulates the imatinib resistance of chronic myeloid leukemia cells by repressing BCR-ABL1 expression.	0
28543796	2017	Mxd1 mediates hypoxia-induced cisplatin resistance in osteosarcoma cells by repression of the PTEN tumor suppressor gene.	13
28543796	2017	Mxd1 mediates hypoxia-induced cisplatin resistance in osteosarcoma cells by repression of the PTEN tumor suppressor gene.	13
26698869	2016	TCP10L synergizes with MAD1 in transcriptional suppression and cell cycle arrest through mutual interaction.	2
27520398	2016	miR-382-5p Controls Hematopoietic Stem Cell Differentiation Through the Downregulation of MXD1.	13
27588501	2016	MXD1 localizes in the nucleolus, binds UBF and impairs rRNA synthesis.	11

Citation

Dessen P

MXD1 (MAX dimerization protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/214/mxd1-(max-dimerization-protein-1)