DEK (DEK proto-oncogene)
1998-01-01 Jean-Loup Huret AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Identity
HGNC
LOCATION
6p22.3
IMAGE
LEGEND
DEK (6p23) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
IMAGE
LEGEND
DEK (DEK proto-oncogene) Hybridization with DEK / NUP214 t(6;9) probe (Kreatech, Leica Biosystems Inc., US) showing DEK gene on 6p22.3 (green signals - Courtesy Adriana Zamecnikova.
LOCUSID
ALIAS
D6S231E
FUSION GENES
DNA/RNA
Description
spans on a 40 kb genomic segment
Transcription
2.7 kb mRNA; coding sequence: 1.1 kb
Proteins
Description
375 amino acids; 43 kDa; contains numerous acidic domains
(Asp/Glu rich) and a nuclear localisation signal
Expression
wide
Localisation
potentially nuclear
Function
site specific DNA binding protein involved in transcriptional
regulation and signal transduction
Implicated in
Entity name
Disease
M2, M4 AML or MDS
Prognosis
remission difficult to obtain
Cytogenetics
this chromosome anomaly may be over loocked
Hybrid gene
5 DEK - 3 CAN; chromosome 6 breakpoint clusters in a single intron
Fusion protein
head to tail DEK/CAN fusion protein (the alternative SET/CAN is
exceptional); almost the entire DEK protein fused to the C-terminal
two-thirds of the CAN protein; nuclear localization
Other Information
Locus ID:
NCBI: 7913
MIM: 125264
HGNC: 2768
Ensembl: ENSG00000124795
Variants:
dbSNP: 7913
ClinVar: 7913
TCGA: ENSG00000124795
COSMIC: DEK
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36535490 | 2023 | Role of DEK in carcinogenesis, diagnosis, prognosis, and therapeutic outcome of breast cancer: An evidence-based clinical review. | 0 |
| 37172756 | 2023 | The impact of the chromatin binding DEK protein in hematopoiesis and acute myeloid leukemia. | 2 |
| 37550322 | 2023 | Imaging-based study demonstrates how the DEK nanoscale distribution differentially correlates with epigenetic marks in a breast cancer model. | 2 |
| 36535490 | 2023 | Role of DEK in carcinogenesis, diagnosis, prognosis, and therapeutic outcome of breast cancer: An evidence-based clinical review. | 0 |
| 37172756 | 2023 | The impact of the chromatin binding DEK protein in hematopoiesis and acute myeloid leukemia. | 2 |
| 37550322 | 2023 | Imaging-based study demonstrates how the DEK nanoscale distribution differentially correlates with epigenetic marks in a breast cancer model. | 2 |
| 35475534 | 2022 | DEK modulates both expression and alternative splicing of cancer‑related genes. | 1 |
| 35563178 | 2022 | Long Non-Coding LEF1-AS1 Sponge miR-5100 Regulates Apoptosis and Autophagy in Gastric Cancer Cells via the miR-5100/DEK/AMPK-mTOR Axis. | 10 |
| 35821094 | 2022 | p21-activated kinase 2 binds to transcription factor SOX2 and up-regulates DEK to promote the progression of lung squamous cell carcinoma. | 0 |
| 35972263 | 2022 | In silico gene expression and pathway analysis of DEK in the human brain across the lifespan. | 1 |
| 36190960 | 2022 | Doxorubicin induces prolonged DNA damage signal in cells overexpressing DEK isoform-2. | 2 |
| 35475534 | 2022 | DEK modulates both expression and alternative splicing of cancer‑related genes. | 1 |
| 35563178 | 2022 | Long Non-Coding LEF1-AS1 Sponge miR-5100 Regulates Apoptosis and Autophagy in Gastric Cancer Cells via the miR-5100/DEK/AMPK-mTOR Axis. | 10 |
| 35821094 | 2022 | p21-activated kinase 2 binds to transcription factor SOX2 and up-regulates DEK to promote the progression of lung squamous cell carcinoma. | 0 |
| 35972263 | 2022 | In silico gene expression and pathway analysis of DEK in the human brain across the lifespan. | 1 |
Citation
Jean-Loup Huret
DEK (DEK proto-oncogene)
Atlas Genet Cytogenet Oncol Haematol. 1998-01-01
Online version: http://atlasgeneticsoncology.org/gene/23/dek-(dek-proto-oncogene)
