DEK (DEK proto-oncogene)

1998-01-01 Jean-Loup Huret Affiliation

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC

DEK

LOCATION

6p22.3

IMAGE

LEGEND

DEK (6p23) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.

IMAGE

LEGEND

DEK (DEK proto-oncogene) Hybridization with DEK / NUP214 t(6;9) probe (Kreatech, Leica Biosystems Inc., US) showing DEK gene on 6p22.3 (green signals - Courtesy Adriana Zamecnikova.

LOCUSID

7913

ALIAS

D6S231E

FUSION GENES

Show Gene Fusions

DNA/RNA

Description

spans on a 40 kb genomic segment

Transcription

2.7 kb mRNA; coding sequence: 1.1 kb

Proteins

Description

375 amino acids; 43 kDa; contains numerous acidic domains (Asp/Glu rich) and a nuclear localisation signal

Expression

wide

Localisation

potentially nuclear

Function

site specific DNA binding protein involved in transcriptional regulation and signal transduction

Implicated in

Entity name

t(6;9)(p23;q34)/AML or MDS --> DEK-CAN

Disease

M2, M4 AML or MDS

Prognosis

remission difficult to obtain

Cytogenetics

this chromosome anomaly may be over loocked

Hybrid gene

5 DEK - 3 CAN; chromosome 6 breakpoint clusters in a single intron

Fusion protein

head to tail DEK/CAN fusion protein (the alternative SET/CAN is exceptional); almost the entire DEK protein fused to the C-terminal two-thirds of the CAN protein; nuclear localization

Other Information

Locus ID:

NCBI: 7913
MIM: 125264
HGNC: 2768
Ensembl: ENSG00000124795

Variants:

dbSNP: 7913
ClinVar: 7913
TCGA: ENSG00000124795
COSMIC: DEK

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000124795	ENST00000244776	P35659
ENSG00000124795	ENST00000503715	D6RDA2
ENSG00000124795	ENST00000505224	B4DFG0
ENSG00000124795	ENST00000507591	H0Y993
ENSG00000124795	ENST00000515742	D6R9L5
ENSG00000124795	ENST00000515770	H0Y8X0
ENSG00000124795	ENST00000651624	A0A494C198
ENSG00000124795	ENST00000651992	A0A494C028
ENSG00000124795	ENST00000652576	P35659
ENSG00000124795	ENST00000652689	P35659

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Epigenetic regulation of gene expression	REACTOME	R-HSA-212165
Positive epigenetic regulation of rRNA expression	REACTOME	R-HSA-5250913
B-WICH complex positively regulates rRNA expression	REACTOME	R-HSA-5250924
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	REACTOME	R-HSA-8864260

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36535490	2023	Role of DEK in carcinogenesis, diagnosis, prognosis, and therapeutic outcome of breast cancer: An evidence-based clinical review.	0
37172756	2023	The impact of the chromatin binding DEK protein in hematopoiesis and acute myeloid leukemia.	2
37550322	2023	Imaging-based study demonstrates how the DEK nanoscale distribution differentially correlates with epigenetic marks in a breast cancer model.	2
36535490	2023	Role of DEK in carcinogenesis, diagnosis, prognosis, and therapeutic outcome of breast cancer: An evidence-based clinical review.	0
37172756	2023	The impact of the chromatin binding DEK protein in hematopoiesis and acute myeloid leukemia.	2
37550322	2023	Imaging-based study demonstrates how the DEK nanoscale distribution differentially correlates with epigenetic marks in a breast cancer model.	2
35475534	2022	DEK modulates both expression and alternative splicing of cancer‑related genes.	1
35563178	2022	Long Non-Coding LEF1-AS1 Sponge miR-5100 Regulates Apoptosis and Autophagy in Gastric Cancer Cells via the miR-5100/DEK/AMPK-mTOR Axis.	10
35821094	2022	p21-activated kinase 2 binds to transcription factor SOX2 and up-regulates DEK to promote the progression of lung squamous cell carcinoma.	0
35972263	2022	In silico gene expression and pathway analysis of DEK in the human brain across the lifespan.	1
36190960	2022	Doxorubicin induces prolonged DNA damage signal in cells overexpressing DEK isoform-2.	2
35475534	2022	DEK modulates both expression and alternative splicing of cancer‑related genes.	1
35563178	2022	Long Non-Coding LEF1-AS1 Sponge miR-5100 Regulates Apoptosis and Autophagy in Gastric Cancer Cells via the miR-5100/DEK/AMPK-mTOR Axis.	10
35821094	2022	p21-activated kinase 2 binds to transcription factor SOX2 and up-regulates DEK to promote the progression of lung squamous cell carcinoma.	0
35972263	2022	In silico gene expression and pathway analysis of DEK in the human brain across the lifespan.	1

Citation

Jean-Loup Huret

DEK (DEK proto-oncogene)

Atlas Genet Cytogenet Oncol Haematol. 1998-01-01

Online version: http://atlasgeneticsoncology.org/gene/23/dek-(dek-proto-oncogene)