TAF15 (TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa)
2000-09-01 Jean-Loup Huret AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Identity
HGNC
LOCATION
17q12
LOCUSID
ALIAS
Npl3,RBP56,TAF2N,TAFII68
FUSION GENES
DNA/RNA
Description
spans 37kb; 16 exons
Transcription
2.2 bp mRNA; alternative splicing: two isoforms of cDNAs consisting of 2144 and 2153 bp; coding sequence 1778 bp
Proteins
Description
589 and 592 amino acid, 62 kDa ; comprises a N-term ser, tyr, gln, gly -rich region, followed by a an RNA binding domain and a Cys2/Cys2 finger motif, and repeats in C-term
Expression
wide; in the fetus and in the adult
Localisation
nuclear
Function
single strand DNA/RNA binding protein; part of theTFIID and RNA polymerase II complex of proteins which assemble on the promoter to form a pre-initiation complex (PIC); TFIID is composed of a TATA-box-binding protein (TBP) and a number of TBP-associated factors (TAFIIS); contribute to the activation of transcription
Mutations
Somatic
overexpression of TAF2N- FLI-1 chimeras in NIH3T3 cells leads to oncogenic transformation
Implicated in
Entity name
Disease
a rare tumour: 2.3% of soft tissue sarcomas often localized in deep soft tissues of the lower extremities
Breakpoints
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 10637511 | 1999 | The N-terminal domain of human TAFII68 displays transactivation and oncogenic properties. | Bertolotti A et al |
| 10664584 | 2000 | TBP-associated factors (TAFIIs): multiple, selective transcriptional mediators in common complexes. | Green MR et al |
| 9795213 | 1998 | Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes. | Morohoshi F et al |
| 10602519 | 1999 | Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11). | Panagopoulos I et al |
| 7935765 | 1994 | Yeast TAFIIS in a multisubunit complex required for activated transcription. | Reese JC et al |
| 10537274 | 1999 | Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma. | Sjögren H et al |
Other Information
Locus ID:
NCBI: 8148
MIM: 601574
HGNC: 11547
Ensembl: ENSG00000270647
Variants:
dbSNP: 8148
ClinVar: 8148
TCGA: ENSG00000270647
COSMIC: TAF15
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38057661 | 2024 | TAF15 amyloid filaments in frontotemporal lobar degeneration. | 5 |
| 38226841 | 2024 | circRNA TATA-box binding protein associated factor 15 acts as an oncogene to facilitate bladder cancer progression through targeting miR-502-5p/high mobility group box 3. | 2 |
| 38811189 | 2024 | circZNF532 promotes endothelial-to-mesenchymal transition in diabetic retinopathy by recruiting TAF15 to stabilize PIK3CD. | 0 |
| 38057661 | 2024 | TAF15 amyloid filaments in frontotemporal lobar degeneration. | 5 |
| 38226841 | 2024 | circRNA TATA-box binding protein associated factor 15 acts as an oncogene to facilitate bladder cancer progression through targeting miR-502-5p/high mobility group box 3. | 2 |
| 38811189 | 2024 | circZNF532 promotes endothelial-to-mesenchymal transition in diabetic retinopathy by recruiting TAF15 to stabilize PIK3CD. | 0 |
| 36895010 | 2023 | CircDNAJC11 interacts with TAF15 to promote breast cancer progression via enhancing MAPK6 expression and activating the MAPK signaling pathway. | 7 |
| 37037864 | 2023 | TAF15 promotes cell proliferation, migration and invasion of gastric cancer via activation of the RAF1/MEK/ERK signalling pathway. | 2 |
| 37257820 | 2023 | m6A-enriched lncRNA LINC00839 promotes tumor progression by enhancing TAF15-mediated transcription of amine oxidase AOC1 in nasopharyngeal carcinoma. | 6 |
| 36895010 | 2023 | CircDNAJC11 interacts with TAF15 to promote breast cancer progression via enhancing MAPK6 expression and activating the MAPK signaling pathway. | 7 |
| 37037864 | 2023 | TAF15 promotes cell proliferation, migration and invasion of gastric cancer via activation of the RAF1/MEK/ERK signalling pathway. | 2 |
| 37257820 | 2023 | m6A-enriched lncRNA LINC00839 promotes tumor progression by enhancing TAF15-mediated transcription of amine oxidase AOC1 in nasopharyngeal carcinoma. | 6 |
| 35228660 | 2022 | LncRNA LINC00649 recruits TAF15 and enhances MAPK6 expression to promote the development of lung squamous cell carcinoma via activating MAPK signaling pathway. | 11 |
| 35643629 | 2022 | The SGYS motif of TAF15 prion-like domain is critical to amyloid fibril formation. | 2 |
| 35228660 | 2022 | LncRNA LINC00649 recruits TAF15 and enhances MAPK6 expression to promote the development of lung squamous cell carcinoma via activating MAPK signaling pathway. | 11 |
Citation
Jean-Loup Huret
TAF15 (TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa)
Atlas Genet Cytogenet Oncol Haematol. 2000-09-01
Online version: http://atlasgeneticsoncology.org/gene/256
