GAS7 (growth arrest-specific 7)
2000-06-01 Jean-Loup Huret AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Identity
HGNC
LOCATION
17p13.1
IMAGE
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
-
FUSION GENES
DNA/RNA
Description
genomic sequence 167 kb; 14 exons
Transcription
8 kb mRNA; various splicings in the mouse
Proteins
Description
412 aa
Expression
in quiescent/terminally differenciated cells, like other GAS (herien the name Growth Arrest-Specific); selective expression in growth-arrested fibroblasts; GAS7 is predominantly expressed in the brain (in particular, in the mouse, in Purkinje cells of the cerebellum, at lower level in other tissues such as the heart and the testes); gas7 expression is associated with neurite formation (and overproduction of gas7 in neuroblastoma cells promotes neurite-like outgrowth) which suggests that GAS7 may have a role in promoting, and possibly maintaining, maturation and morphological differentiation of cerebellar neurons
Implicated in
Entity name
treatment-related acute non lymphocytic leukemia with t(11;17)(q23;p13)
Disease
only one case: a 13-year-old boy, with a M4 AML and a karyotype with an apparent del(11)(q23) (finally proved to be in reality a cryptic t(11;17)(q23;p13)); four months later the patient died; other cases of t(11;17)(q23;p13) have been described but the involvement of GAS7 has not been proved
Hybrid gene
5 MLL-3 GAS7; breakpoint in MLL intron 8, in MLL bcr; GAS7 breakpoint upstream of exon 1; fusion of mLL exon 7 or exon 8 to GAS7 exon 2
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 9736752 | 1998 | gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation. | Ju YT et al |
| 10706619 | 2000 | Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors. | Megonigal MD et al |
Other Information
Locus ID:
NCBI: 8522
MIM: 603127
HGNC: 4169
Ensembl: ENSG00000007237
Variants:
dbSNP: 8522
ClinVar: 8522
TCGA: ENSG00000007237
COSMIC: GAS7
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38429909 | 2024 | Adipose stem cell-derived exosomes promote wound healing by regulating the let-7i-5p/GAS7 axis. | 0 |
| 38429909 | 2024 | Adipose stem cell-derived exosomes promote wound healing by regulating the let-7i-5p/GAS7 axis. | 0 |
| 36908025 | 2023 | Circ_0078607 increases platinum drug sensitivity via miR-196b-5p/GAS7 axis in ovarian cancer. | 3 |
| 37769891 | 2023 | Gas7 attenuates hepatocellular carcinoma progression and chemoresistance through the PI3K/Akt signaling pathway. | 0 |
| 38240248 | 2023 | Single-nucleotide polymorphisms of TLR4 and GAS7 linked to primary open-angle glaucoma among patients of Shenyang, China. | 0 |
| 36908025 | 2023 | Circ_0078607 increases platinum drug sensitivity via miR-196b-5p/GAS7 axis in ovarian cancer. | 3 |
| 37769891 | 2023 | Gas7 attenuates hepatocellular carcinoma progression and chemoresistance through the PI3K/Akt signaling pathway. | 0 |
| 38240248 | 2023 | Single-nucleotide polymorphisms of TLR4 and GAS7 linked to primary open-angle glaucoma among patients of Shenyang, China. | 0 |
| 35400990 | 2022 | Association of ABCA1 (rs2472493) and GAS7 (rs9913911) gene variants with primary open-angle glaucoma in a Brazilian population. | 3 |
| 35400990 | 2022 | Association of ABCA1 (rs2472493) and GAS7 (rs9913911) gene variants with primary open-angle glaucoma in a Brazilian population. | 3 |
| 33602789 | 2021 | GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma. | 10 |
| 33602789 | 2021 | GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma. | 10 |
| 32216967 | 2020 | Growth arrest specific protein 7 inhibits tau fibrillogenesis. | 4 |
| 32216967 | 2020 | Growth arrest specific protein 7 inhibits tau fibrillogenesis. | 4 |
| 31269845 | 2019 | Association of polymorphism rs11656696 in GAS7 with primary open-Angle Glaucoma in a Chinese Population. | 5 |
Citation
Jean-Loup Huret
GAS7 (growth arrest-specific 7)
Atlas Genet Cytogenet Oncol Haematol. 2000-06-01
Online version: http://atlasgeneticsoncology.org/gene/257/gas7
