GAS7 (growth arrest-specific 7)

2000-06-01   Jean-Loup Huret  

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
LOCATION
17p13.1
IMAGE
Atlas Image
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
-
FUSION GENES

DNA/RNA

Description

genomic sequence 167 kb; 14 exons

Transcription

8 kb mRNA; various splicings in the mouse

Proteins

Description

412 aa

Expression

in quiescent/terminally differenciated cells, like other GAS (herien the name Growth Arrest-Specific); selective expression in growth-arrested fibroblasts; GAS7 is predominantly expressed in the brain (in particular, in the mouse, in Purkinje cells of the cerebellum, at lower level in other tissues such as the heart and the testes); gas7 expression is associated with neurite formation (and overproduction of gas7 in neuroblastoma cells promotes neurite-like outgrowth) which suggests that GAS7 may have a role in promoting, and possibly maintaining, maturation and morphological differentiation of cerebellar neurons

Implicated in

Entity name
treatment-related acute non lymphocytic leukemia with t(11;17)(q23;p13)
Disease
only one case: a 13-year-old boy, with a M4 AML and a karyotype with an apparent del(11)(q23) (finally proved to be in reality a cryptic t(11;17)(q23;p13)); four months later the patient died; other cases of t(11;17)(q23;p13) have been described but the involvement of GAS7 has not been proved
Hybrid gene
5 MLL-3 GAS7; breakpoint in MLL intron 8, in MLL bcr; GAS7 breakpoint upstream of exon 1; fusion of mLL exon 7 or exon 8 to GAS7 exon 2

Article Bibliography

Pubmed IDLast YearTitleAuthors
97367521998gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation.Ju YT et al
107066192000Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors.Megonigal MD et al

Other Information

Locus ID:

NCBI: 8522
MIM: 603127
HGNC: 4169
Ensembl: ENSG00000007237

Variants:

dbSNP: 8522
ClinVar: 8522
TCGA: ENSG00000007237
COSMIC: GAS7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000007237ENST00000396115A0A0A0MS68
ENSG00000007237ENST00000432992O60861
ENSG00000007237ENST00000578599J3QS26
ENSG00000007237ENST00000580043J3QLH8
ENSG00000007237ENST00000583882J3QR80
ENSG00000007237ENST00000584146J3KS47
ENSG00000007237ENST00000584389J3KTB1

Expression (GTEx)

0
50
100
150
200
250
300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
384299092024Adipose stem cell-derived exosomes promote wound healing by regulating the let-7i-5p/GAS7 axis.0
384299092024Adipose stem cell-derived exosomes promote wound healing by regulating the let-7i-5p/GAS7 axis.0
369080252023Circ_0078607 increases platinum drug sensitivity via miR-196b-5p/GAS7 axis in ovarian cancer.3
377698912023Gas7 attenuates hepatocellular carcinoma progression and chemoresistance through the PI3K/Akt signaling pathway.0
382402482023Single-nucleotide polymorphisms of TLR4 and GAS7 linked to primary open-angle glaucoma among patients of Shenyang, China.0
369080252023Circ_0078607 increases platinum drug sensitivity via miR-196b-5p/GAS7 axis in ovarian cancer.3
377698912023Gas7 attenuates hepatocellular carcinoma progression and chemoresistance through the PI3K/Akt signaling pathway.0
382402482023Single-nucleotide polymorphisms of TLR4 and GAS7 linked to primary open-angle glaucoma among patients of Shenyang, China.0
354009902022Association of ABCA1 (rs2472493) and GAS7 (rs9913911) gene variants with primary open-angle glaucoma in a Brazilian population.3
354009902022Association of ABCA1 (rs2472493) and GAS7 (rs9913911) gene variants with primary open-angle glaucoma in a Brazilian population.3
336027892021GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma.10
336027892021GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma.10
322169672020Growth arrest specific protein 7 inhibits tau fibrillogenesis.4
322169672020Growth arrest specific protein 7 inhibits tau fibrillogenesis.4
312698452019Association of polymorphism rs11656696 in GAS7 with primary open-Angle Glaucoma in a Chinese Population.5

Citation

Jean-Loup Huret

GAS7 (growth arrest-specific 7)

Atlas Genet Cytogenet Oncol Haematol. 2000-06-01

Online version: http://atlasgeneticsoncology.org/gene/257/gas7-(growth-arrest-specific-7)