RAP1A (RAP11, member of RAS oncogene family)
2001-05-01 Jean de Gunzburg AffiliationLaboratoire de Signalisation Intracellulaire et Oncogenöse INSERM U-528 Institut Curie Section de Recherche 26, rue dUlm, 75248 Paris Cedex 05, France
Identity
HGNC
LOCATION
1p13.2
IMAGE
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
C21KG,G-22K,KREV-1,KREV1,RAP1,SMGP21
FUSION GENES
DNA/RNA
Description
6 coding exons covering 18095 bp on chromosome 1
Proteins
Expression
ubiquitous ; higher in brain and hemopoïetic tissues
Localisation
Rap1 is bound to membranes. In many cell types, it is found in a perinuclear compartment overlapping the Golgi. Rap1 proteins (A and B) are phosphorylated near the C-ter by cAMP-dependent protein kinase. This results in translocation of part of the Rap1 pool to the cytosol.
Function
The function of Rap1 is still a matter of debate. Its overexpression is able to compete with the activation of Raf-1 by active Ras. Active Rap1B has been shown to activate the B-Raf kinase and the MEK-ERK cascade. In several cellular models, Rap1 has been shown to be involved in the regulation of integrin-mediated cell adhesion.
Homology
95% to Rap1B, 60% identical to Rap2, 50 % to Ras proteins
Mutations
Germinal
unknown
Implicated in
Entity name
no implication in pathologies characterized so far
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 11331911 | 2001 | Rap1 signalling: adhering to new models. | Bos JL et al |
Other Information
Locus ID:
NCBI: 5906
MIM: 179520
HGNC: 9855
Ensembl: ENSG00000116473
Variants:
dbSNP: 5906
ClinVar: 5906
TCGA: ENSG00000116473
COSMIC: RAP1A
RNA/Proteins
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38682208 | 2024 | Activation of the MEK/ERK Pathway Mediates the Inhibitory Effects of Silvestrol on Nasopharyngeal Carcinoma Cells via RAP1A, HK2, and GADD45A. | 0 |
| 38682208 | 2024 | Activation of the MEK/ERK Pathway Mediates the Inhibitory Effects of Silvestrol on Nasopharyngeal Carcinoma Cells via RAP1A, HK2, and GADD45A. | 0 |
| 35294066 | 2022 | ArhGEF12 activates Rap1A and not RhoA in human dermal microvascular endothelial cells to reduce tumor necrosis factor-induced leak. | 2 |
| 35294066 | 2022 | ArhGEF12 activates Rap1A and not RhoA in human dermal microvascular endothelial cells to reduce tumor necrosis factor-induced leak. | 2 |
| 33087256 | 2021 | Natural Killer Cell Transcript 4 promotes the development of Sjӧgren's syndrome via activation of Rap1 on B cells. | 0 |
| 33482197 | 2021 | Identification of Radil as a Ras binding partner and putative activator. | 5 |
| 33748908 | 2021 | Involvement of miR-337 in high glucose-suppressed osteogenic differentiation in bone marrow mesenchymal stem cells via negative regulation of Rap1A. | 3 |
| 34602545 | 2021 | Rap1 Small GTPase Regulates Vascular Endothelial-Cadherin-Mediated Endothelial Cell-Cell Junctions and Vascular Permeability. | 10 |
| 33087256 | 2021 | Natural Killer Cell Transcript 4 promotes the development of Sjӧgren's syndrome via activation of Rap1 on B cells. | 0 |
| 33482197 | 2021 | Identification of Radil as a Ras binding partner and putative activator. | 5 |
| 33748908 | 2021 | Involvement of miR-337 in high glucose-suppressed osteogenic differentiation in bone marrow mesenchymal stem cells via negative regulation of Rap1A. | 3 |
| 34602545 | 2021 | Rap1 Small GTPase Regulates Vascular Endothelial-Cadherin-Mediated Endothelial Cell-Cell Junctions and Vascular Permeability. | 10 |
| 31805277 | 2020 | MiR-501-3p functions as a tumor suppressor in non-small cell lung cancer by downregulating RAP1A. | 10 |
| 32182086 | 2020 | Long noncoding RNA CRNDE promotes proliferation, migration and invasion in prostate cancer through miR-101/Rap1A. | 6 |
| 32184389 | 2020 | Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability. | 30 |
Citation
Jean de Gunzburg
RAP1A (RAP11, member of RAS oncogene family)
Atlas Genet Cytogenet Oncol Haematol. 2001-05-01
Online version: http://atlasgeneticsoncology.org/gene/272/rap1a
