RAP1B (RAP1B, member of RAS oncogene family)
2001-05-01 Jean de Gunzburg AffiliationLaboratoire de Signalisation Intracellulaire et Oncogenöse INSERM U-528 Institut Curie Section de Recherche 26, rue dUlm, 75248 Paris Cedex 05, France
DNA/RNA
Description
The gene emcompasses 7 codinng exons covering 10779 bp on chromosome 12
Proteins
Expression
ubiquitous ; highest in platelets and neutrophils
Localisation
Rap1 is bound to membranes. In many cell types, it is found in a perinuclear compartment overlapping the Golgi. Rap1 proteins (A and B) are phosphorylated near the C-ter by cAMP-dependent protein kinase. This results in translocation of part of the Rap1 pool to the cytosol.
Function
The function of Rap1 is still a matter of debate. Its overexpression is able to compete with the activation of Raf-1 by active Ras. Active Rap1B has been shown to activate the B-Raf kinase and the MEK-ERK cascade. In several cellular models, Rap1 has been shown to be involved in the regulation of integrin-mediated cell adhesion.
Homology
98% identical to Rap1A, 60% identical to Rap2 , 50 % to Ras proteins
Mutations
Germinal
unknown
Implicated in
Entity name
no implication in pathologies characterized so far
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 11331911 | 2001 | Rap1 signalling: adhering to new models. | Bos JL et al |
Other Information
Locus ID:
NCBI: 5908
MIM: 179530
HGNC: 9857
Ensembl: ENSG00000127314
Variants:
dbSNP: 5908
ClinVar: 5908
TCGA: ENSG00000127314
COSMIC: RAP1B
RNA/Proteins
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37850357 | 2024 | Adding to the evidence of gene-disease association of RAP1B and syndromic thrombocytopenia. | 0 |
| 37850357 | 2024 | Adding to the evidence of gene-disease association of RAP1B and syndromic thrombocytopenia. | 0 |
| 36951484 | 2023 | Roles of the hsa_circ_0013880/USP32/Rap1b axis in the proliferation and apoptosis of acute myeloid leukemia cells. | 3 |
| 37515145 | 2023 | ICP4-Associated Activation of Rap1b Facilitates Herpes Simplex Virus Type I (HSV-1) Infection in Human Corneal Epithelial Cells. | 0 |
| 36951484 | 2023 | Roles of the hsa_circ_0013880/USP32/Rap1b axis in the proliferation and apoptosis of acute myeloid leukemia cells. | 3 |
| 37515145 | 2023 | ICP4-Associated Activation of Rap1b Facilitates Herpes Simplex Virus Type I (HSV-1) Infection in Human Corneal Epithelial Cells. | 0 |
| 36056690 | 2022 | SNORA70E promotes the occurrence and development of ovarian cancer through pseudouridylation modification of RAP1B and alternative splicing of PARPBP. | 9 |
| 36056690 | 2022 | SNORA70E promotes the occurrence and development of ovarian cancer through pseudouridylation modification of RAP1B and alternative splicing of PARPBP. | 9 |
| 34306997 | 2021 | LINC00665 Facilitates the Malignant Processes of Osteosarcoma by Increasing the RAP1B Expression via Sponging miR-708 and miR-142-5p. | 7 |
| 34306997 | 2021 | LINC00665 Facilitates the Malignant Processes of Osteosarcoma by Increasing the RAP1B Expression via Sponging miR-708 and miR-142-5p. | 7 |
| 31738148 | 2020 | MiR-181a Reduces Platelet Activation via the Inhibition of Endogenous RAP1B. | 6 |
| 31877303 | 2020 | miR-200b/c-RAP1B axis represses tumorigenesis and malignant progression of papillary thyroid carcinoma through inhibiting the NF-κB/Twist1 pathway. | 10 |
| 32112903 | 2020 | MicroRNA-30b-5p functions as a metastasis suppressor in colorectal cancer by targeting Rap1b. | 13 |
| 32184389 | 2020 | Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability. | 30 |
| 32191497 | 2020 | Long Noncoding RNA LUADT1 Is Upregulated in Melanoma and May Sponge miR-28-5p to Upregulate RAP1B. | 8 |
Citation
Jean de Gunzburg
RAP1B (RAP1B, member of RAS oncogene family)
Atlas Genet Cytogenet Oncol Haematol. 2001-05-01
Online version: http://atlasgeneticsoncology.org/gene/273/rap1b-(rap1b-member-of-ras-oncogene-family)
