RAP2A (RAP2A, member of RAS oncogene family)

2001-05-01   Jean de Gunzburg 

Laboratoire de Signalisation Intracellulaire et Oncogenöse INSERM U-528 Institut Curie Section de Recherche 26, rue dUlm, 75248 Paris Cedex 05, France

Identity

HGNC
LOCATION
13q32.1
LOCUSID
ALIAS
K-REV,KREV,RAP2,RbBP-30
FUSION GENES

DNA/RNA

Atlas Image

Description

The gene contains 2 coding exons separated by a large (29,418 bp) intron covering a total of 30,065 bp on chromosome 13

Proteins

Expression

ubiquitous ; higher in brain and hemopoIetic tissues

Localisation

plasma and/or intracellular membranes (endoplasmic reticulum)

Function

unknonw

Homology

90% identical to Rap2B, 60% identical to Rap1, 50 % to Ras proteins

Mutations

Germinal

unknown

Implicated in

Entity name
no implication in pathologies characterized so far

Bibliography

Pubmed IDLast YearTitleAuthors
19235071991Post-translational processing and subcellular localization of the Ras-related Rap2 protein.Béranger F et al
95237001998Identification of a specific effector of the small GTP-binding protein Rap2.Janoueix-Lerosey I et al
19002901991The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis.Lerosey I et al
109131892000Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade.Ohba Y et al
30457291988Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region.Pizon V et al

Other Information

Locus ID:

NCBI: 5911
MIM: 179540
HGNC: 9861
Ensembl: ENSG00000125249

Variants:

dbSNP: 5911
ClinVar: 5911
TCGA: ENSG00000125249
COSMIC: RAP2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125249ENST00000245304P10114
ENSG00000125249ENST00000476869F6U784

Expression (GTEx)

0
10
20
30
40
50
60

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
227975972012Rap2A links intestinal cell polarity to brush border formation.46
187016802008Constitutively active Rap2 transgenic mice display fewer dendritic spines, reduced extracellular signal-regulated kinase signaling, enhanced long-term depression, and impaired spatial learning and fear extinction.45
153426392004The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton.42
149661412004Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase.40
301355822018RAP2 mediates mechanoresponses of the Hippo pathway.40
255334682015Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases.22
162461752006Biochemical characterization of RGS14: RGS14 activity towards G-protein alpha subunits is independent of its binding to Rap2A.12
169634532006Nitric oxide produced in response to engagement of beta2 integrins on human neutrophils activates the monomeric GTPases Rap1 and Rap2 and promotes adhesion.12
177169792007Characterization of interactions of adapter protein RAPL/Nore1B with RAP GTPases and their role in T cell migration.12
257285122015Rap2a is a novel target gene of p53 and regulates cancer cell migration and invasion.12

Citation

Jean de Gunzburg

RAP2A (RAP2A, member of RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2001-05-01

Online version: http://atlasgeneticsoncology.org/gene/274/rap2a-(rap2a-member-of-ras-oncogene-family)