RAP2B (RAP2B, member of RAS oncogene family)

2001-05-01   Jean de Gunzburg 

Laboratoire de Signalisation Intracellulaire et Oncogenöse INSERM U-528 Institut Curie Section de Recherche 26, rue dUlm, 75248 Paris Cedex 05, France

Identity

HGNC
LOCATION
3q25.2
IMAGE
Atlas Image
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
-
FUSION GENES

DNA/RNA

Atlas Image

Description

The gene contains 1 coding exon only covering 644 bp

Proteins

Expression

ubiquitous ; higher in brain and hemopoietic tissues (especially rich in platelets and meutrophils)

Localisation

plasma and/or intracellular membranes (endoplasmic reticulum)

Function

unknown

Homology

90% identical to Rap2A, 60% identical to Rap1, 50 % to Ras proteins

Mutations

Germinal

unknown

Implicated in

Entity name
no implication in pathologies characterized so far

Bibliography

Pubmed IDLast YearTitleAuthors
109131892000Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade.Ohba Y et al

Other Information

Locus ID:

NCBI: 5912
MIM: 179541
HGNC: 9862
Ensembl: ENSG00000181467

Variants:

dbSNP: 5912
ClinVar: 5912
TCGA: ENSG00000181467
COSMIC: RAP2B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181467ENST00000323534P61225

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
204710302010Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.42
173168882007Identification of genes differentially expressed in human primary lung squamous cell carcinoma.29
118774312002Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B.24
256634602015miR-342-3p targets RAP2B to suppress proliferation and invasion of non-small cell lung cancer cells.24
235352972013Rap2b, a novel p53 target, regulates p53-mediated pro-survival function.22
235352972013Rap2b, a novel p53 target, regulates p53-mediated pro-survival function.22
271330662016MiR-194 inhibits cell proliferation and invasion via repression of RAP2B in bladder cancer.15
284095472018Long Noncoding RNA XIST Promotes Osteosarcoma Progression by Targeting Ras-Related Protein RAP2B via miR-320b.14
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11

Citation

Jean de Gunzburg

RAP2B (RAP2B, member of RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2001-05-01

Online version: http://atlasgeneticsoncology.org/gene/275/rap2b-(rap2b-member-of-ras-oncogene-family)