TFG (TRK-fused gene)
2004-09-01 Masanori Hisaoka , Hiroshi Hashimoto AffiliationDepartment of Pathology & Oncology, School of Medicine, University of Occupational & Environmental Health, Japan
Identity
HGNC
LOCATION
3q12.2
IMAGE
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
HMSNP,SPG57,TF6,TRKT3
FUSION GENES
DNA/RNA
Description
39.51 kbp
Transcription
8 exons; 1948 bp mRNA.
Pseudogene
one (NB5M_HUMAN.Human.2.v2.chr1C.mbl.220)
Proteins
Description
Expression
Ubiquitously expressed.
Localisation
Not examined (TFG-ALK fusion protein is localized in cytoplasm).
Function
unknown
Homology
Homologous to murine Tfg.
Implicated in
Entity name
Cytogenetics
Hybrid gene
TFG-ALK
Fusion protein
TFG-ALK(S)(85 kD), TFG-ALK(L)(97 kD), TFG-ALK(XL)(113 kD)
Entity name
Thyroid papillary carcinoma
Cytogenetics
t(1;3)(q21;q11)
Hybrid gene
TFG-NTRK1
Fusion protein
TFG-NTRK1
Entity name
Hybrid gene
TFG-NR4A3
Breakpoints
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 7565764 | 1995 | The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain. | Greco A et al |
| 11943732 | 2002 | Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity. | Hernández L et al |
| 15188455 | 2004 | TFG is a novel fusion partner of NOR1 in extraskeletal myxoid chondrosarcoma. | Hisaoka M et al |
| 9169129 | 1997 | Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma. | Mencinger M et al |
Other Information
Locus ID:
NCBI: 10342
MIM: 602498
HGNC: 11758
Ensembl: ENSG00000114354
Variants:
dbSNP: 10342
ClinVar: 10342
TCGA: ENSG00000114354
COSMIC: TFG
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37890998 | 2024 | Novel TFG mutation causes autosomal-dominant spastic paraplegia and defects in autophagy. | 1 |
| 38533668 | 2024 | Hereditary motor sensory neuropathy with proximal involvement (HMSN-P) associated with TFG p.Pro285Leu variant in an Italian family with a motor neuron disease-like clinical picture. | 0 |
| 37890998 | 2024 | Novel TFG mutation causes autosomal-dominant spastic paraplegia and defects in autophagy. | 1 |
| 38533668 | 2024 | Hereditary motor sensory neuropathy with proximal involvement (HMSN-P) associated with TFG p.Pro285Leu variant in an Italian family with a motor neuron disease-like clinical picture. | 0 |
| 36464850 | 2023 | TFG::MET-rearranged soft tissue tumor: A rare infantile neoplasm with a distinct low-grade triphasic morphology. | 0 |
| 36464850 | 2023 | TFG::MET-rearranged soft tissue tumor: A rare infantile neoplasm with a distinct low-grade triphasic morphology. | 0 |
| 34779525 | 2022 | A Novel TFG Mutation in a Korean Family with α-Synucleinopathy and Amyotrophic Lateral Sclerosis. | 3 |
| 35642252 | 2022 | Mutation Screening of TFG in α-Synucleinopathy and Amyotrophic Lateral Sclerosis. | 1 |
| 35986567 | 2022 | TFG mutation induces haploinsufficiency and drives axonal Charcot-Marie-Tooth disease by causing neurite degeneration. | 2 |
| 34779525 | 2022 | A Novel TFG Mutation in a Korean Family with α-Synucleinopathy and Amyotrophic Lateral Sclerosis. | 3 |
| 35642252 | 2022 | Mutation Screening of TFG in α-Synucleinopathy and Amyotrophic Lateral Sclerosis. | 1 |
| 35986567 | 2022 | TFG mutation induces haploinsufficiency and drives axonal Charcot-Marie-Tooth disease by causing neurite degeneration. | 2 |
| 33767317 | 2021 | Homozygous TFG gene variants expanding the mutational and clinical spectrum of hereditary spastic paraplegia 57 and a review of literature. | 2 |
| 33932238 | 2021 | TFG binds LC3C to regulate ULK1 localization and autophagosome formation. | 11 |
| 34185412 | 2021 | Deregulation of CLTC interacts with TFG, facilitating osteosarcoma via the TGF-beta and AKT/mTOR signaling pathways. | 5 |
Citation
Masanori Hisaoka ; Hiroshi Hashimoto
TFG (TRK-fused gene)
Atlas Genet Cytogenet Oncol Haematol. 2004-09-01
Online version: http://atlasgeneticsoncology.org/gene/281/tfg
