TFG (TRK-fused gene)

2004-09-01   Masanori Hisaoka  , Hiroshi Hashimoto  

Department of Pathology & Oncology, School of Medicine, University of Occupational & Environmental Health, Japan

Identity

HGNC
TFG
LOCATION
3q12.2
IMAGE
Atlas Image
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
10342
ALIAS
HMSNP,SPG57,TF6,TRKT3
FUSION GENES
Show Gene Fusions

DNA/RNA

Description

39.51 kbp

Transcription

8 exons; 1948 bp mRNA.

Pseudogene

one (NB5M_HUMAN.Human.2.v2.chr1C.mbl.220)

Proteins

Description

400-amino acid protein with a putative N-terminal coiled-coil structure and an SPYGQ-rich region similar to N-terminal parts of EWSR1 and FUS.

Expression

Ubiquitously expressed.

Localisation

Not examined (TFG-ALK fusion protein is localized in cytoplasm).

Function

unknown

Homology

Homologous to murine Tfg.

Implicated in

Entity name
Anaplastic large cell lymphoma
Cytogenetics
t(2;3)(p23;q21)
Hybrid gene
TFG-ALK
Fusion protein
TFG-ALK(S)(85 kD), TFG-ALK(L)(97 kD), TFG-ALK(XL)(113 kD)
Entity name
Thyroid papillary carcinoma
Cytogenetics
t(1;3)(q21;q11)
Hybrid gene
TFG-NTRK1
Fusion protein
TFG-NTRK1
Entity name
Extraskeletal myxoid chondrosarcoma
Hybrid gene
TFG-NR4A3

Breakpoints

Atlas Image
Atlas Image

Article Bibliography

Pubmed IDLast YearTitleAuthors
75657641995The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain.Greco A et al
119437322002Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity.Hernández L et al
151884552004TFG is a novel fusion partner of NOR1 in extraskeletal myxoid chondrosarcoma.Hisaoka M et al
91691291997Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma.Mencinger M et al

Other Information

Locus ID:

NCBI: 10342
MIM: 602498
HGNC: 11758
Ensembl: ENSG00000114354

Variants:

dbSNP: 10342
ClinVar: 10342
TCGA: ENSG00000114354
COSMIC: TFG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114354ENST00000240851Q92734
ENSG00000114354ENST00000418917Q92734
ENSG00000114354ENST00000463568C9JUE0
ENSG00000114354ENST00000476228Q92734
ENSG00000114354ENST00000479672C9JTY3
ENSG00000114354ENST00000487505C9JJP5
ENSG00000114354ENST00000490574Q92734
ENSG00000114354ENST00000615993Q92734
ENSG00000114354ENST00000620299Q92734

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Thyroid cancerKEGGko05216
Pathways in cancerKEGGhsa05200
Thyroid cancerKEGGhsa05216
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378909982024Novel TFG mutation causes autosomal-dominant spastic paraplegia and defects in autophagy.1
385336682024Hereditary motor sensory neuropathy with proximal involvement (HMSN-P) associated with TFG p.Pro285Leu variant in an Italian family with a motor neuron disease-like clinical picture.0
378909982024Novel TFG mutation causes autosomal-dominant spastic paraplegia and defects in autophagy.1
385336682024Hereditary motor sensory neuropathy with proximal involvement (HMSN-P) associated with TFG p.Pro285Leu variant in an Italian family with a motor neuron disease-like clinical picture.0
364648502023TFG::MET-rearranged soft tissue tumor: A rare infantile neoplasm with a distinct low-grade triphasic morphology.0
364648502023TFG::MET-rearranged soft tissue tumor: A rare infantile neoplasm with a distinct low-grade triphasic morphology.0
347795252022A Novel TFG Mutation in a Korean Family with α-Synucleinopathy and Amyotrophic Lateral Sclerosis.3
356422522022Mutation Screening of TFG in α-Synucleinopathy and Amyotrophic Lateral Sclerosis.1
359865672022TFG mutation induces haploinsufficiency and drives axonal Charcot-Marie-Tooth disease by causing neurite degeneration.2
347795252022A Novel TFG Mutation in a Korean Family with α-Synucleinopathy and Amyotrophic Lateral Sclerosis.3
356422522022Mutation Screening of TFG in α-Synucleinopathy and Amyotrophic Lateral Sclerosis.1
359865672022TFG mutation induces haploinsufficiency and drives axonal Charcot-Marie-Tooth disease by causing neurite degeneration.2
337673172021Homozygous TFG gene variants expanding the mutational and clinical spectrum of hereditary spastic paraplegia 57 and a review of literature.2
339322382021TFG binds LC3C to regulate ULK1 localization and autophagosome formation.11
341854122021Deregulation of CLTC interacts with TFG, facilitating osteosarcoma via the TGF-beta and AKT/mTOR signaling pathways.5

Citation

Masanori Hisaoka ; Hiroshi Hashimoto

TFG (TRK-fused gene)

Atlas Genet Cytogenet Oncol Haematol. 2004-09-01

Online version: http://atlasgeneticsoncology.org/gene/281/tfg-(trk-fused-gene)