TGFA (transforming growth factor alpha)

2003-02-01  

Identity

HGNC
LOCATION
2p13.3
LOCUSID
ALIAS
TFGA
FUSION GENES

Other Information

Locus ID:

NCBI: 7039
MIM: 190170
HGNC: 11765
Ensembl: ENSG00000163235

Variants:

dbSNP: 7039
ClinVar: 7039
TCGA: ENSG00000163235
COSMIC: TGFA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163235ENST00000295400P01135
ENSG00000163235ENST00000394241F8WA74
ENSG00000163235ENST00000418333P01135
ENSG00000163235ENST00000419940H0Y6S5
ENSG00000163235ENST00000444975F8VNR3
ENSG00000163235ENST00000445399P01135
ENSG00000163235ENST00000450929E7EPT6

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
ErbB signaling pathwayKEGGko04012
Renal cell carcinomaKEGGko05211
Pancreatic cancerKEGGko05212
GliomaKEGGko05214
Prostate cancerKEGGko05215
Non-small cell lung cancerKEGGko05223
ErbB signaling pathwayKEGGhsa04012
Pathways in cancerKEGGhsa05200
Renal cell carcinomaKEGGhsa05211
Pancreatic cancerKEGGhsa05212
GliomaKEGGhsa05214
Prostate cancerKEGGhsa05215
Non-small cell lung cancerKEGGhsa05223
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Cargo concentration in the ERREACTOMER-HSA-5694530
EGFR tyrosine kinase inhibitor resistanceKEGGko01521
EGFR tyrosine kinase inhibitor resistanceKEGGhsa01521
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsREACTOMER-HSA-8864260
TFAP2 (AP-2) family regulates transcription of growth factors and their receptorsREACTOMER-HSA-8866910

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10040cetuximabChemicalPathwayassociated
PA162373091panitumumabChemicalPathwayassociated

References

Pubmed IDYearTitleCitations
381520442024TGFA expression is associated with poor prognosis and promotes the development of cervical cancer.1
381520442024TGFA expression is associated with poor prognosis and promotes the development of cervical cancer.1
376862132023EGF, TGF-α and Amphiregulin Differently Regulate Endometrium-Derived Mesenchymal Stromal/Stem Cells.1
376862132023EGF, TGF-α and Amphiregulin Differently Regulate Endometrium-Derived Mesenchymal Stromal/Stem Cells.1
350751622022Genetic markers for non-syndromic orofacial clefts in populations of European ancestry: a meta-analysis.5
358042632022CircRTN1 acts as a miR-431-5p sponge to promote thyroid cancer progression by upregulating TGFA.0
360687592022Autocrine TGF-alpha is associated with Benzo(a)pyrene-induced mucus production and MUC5AC expression during allergic asthma.3
350751622022Genetic markers for non-syndromic orofacial clefts in populations of European ancestry: a meta-analysis.5
358042632022CircRTN1 acts as a miR-431-5p sponge to promote thyroid cancer progression by upregulating TGFA.0
360687592022Autocrine TGF-alpha is associated with Benzo(a)pyrene-induced mucus production and MUC5AC expression during allergic asthma.3
332001922021IRF6, MSX1, TGFA, dental anomalies, and skeletal malocclusion.3
334809842021MicroRNA-374b inhibits breast cancer progression through regulating CCND1 and TGFA genes.7
336619952021LncRNA LINC00857 strengthens the malignancy behaviors of pancreatic adenocarcinoma cells by serving as a competing endogenous RNA for miR-340-5p to upregulate TGFA expression.10
343018212021The Aryl Hydrocarbon Receptor-Dependent TGF-α/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis.7
343998072021Altered proTGFα/cleaved TGFα ratios offer new therapeutic strategies in renal carcinoma.0

Citation

Dessen P

TGFA (transforming growth factor alpha)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/32/tgfa-(transforming-growth-factor-alpha)