Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1021
MIM: 603368
HGNC: 1777
Ensembl: ENSG00000105810
Variants:
dbSNP: 1021
ClinVar: 1021
TCGA: ENSG00000105810
COSMIC: CDK6
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000105810 | ENST00000265734 | Q00534 |
| ENSG00000105810 | ENST00000424848 | Q00534 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA444552 | Hypertension | Disease | Literature, MultilinkAnnotation | associated | 24560520 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38378843 | 2024 | Deregulation of the p19/CDK4/CDK6 axis in Jak2(V617F) megakaryocytes accelerates the development of myelofibrosis. | 0 |
| 38422911 | 2024 | Long noncoding RNA LINC00675 drives malignancy in acute myeloid leukemia via the miR-6809 -CDK6 axis. | 1 |
| 38588409 | 2024 | Comprehensive Transcriptomic Analysis of EWSR1::WT1 Targets Identifies CDK4/6 Inhibitors as an Effective Therapy for Desmoplastic Small Round Cell Tumors. | 0 |
| 38626179 | 2024 | CircPRMT5 promotes progression of osteosarcoma by recruiting CNBP to regulate the translation and stability of CDK6 mRNA. | 0 |
| 38684032 | 2024 | Kinase-inactivated CDK6 preserves the long-term functionality of adult hematopoietic stem cells. | 0 |
| 38378843 | 2024 | Deregulation of the p19/CDK4/CDK6 axis in Jak2(V617F) megakaryocytes accelerates the development of myelofibrosis. | 0 |
| 38422911 | 2024 | Long noncoding RNA LINC00675 drives malignancy in acute myeloid leukemia via the miR-6809 -CDK6 axis. | 1 |
| 38588409 | 2024 | Comprehensive Transcriptomic Analysis of EWSR1::WT1 Targets Identifies CDK4/6 Inhibitors as an Effective Therapy for Desmoplastic Small Round Cell Tumors. | 0 |
| 38626179 | 2024 | CircPRMT5 promotes progression of osteosarcoma by recruiting CNBP to regulate the translation and stability of CDK6 mRNA. | 0 |
| 38684032 | 2024 | Kinase-inactivated CDK6 preserves the long-term functionality of adult hematopoietic stem cells. | 0 |
| 36768557 | 2023 | Deciphering the Immunomodulatory Role of Cyclin-Dependent Kinase 4/6 Inhibitors in the Tumor Microenvironment. | 3 |
| 36884374 | 2023 | CDK6 activity in a recurring convergent kinase network motif. | 0 |
| 37023643 | 2023 | Prognostic significance of CDK6 amplification in esophageal squamous cell carcinoma. | 1 |
| 37081792 | 2023 | CDK6 is activated by the atypical cyclin I to promote E2F-mediated gene expression and cancer cell proliferation. | 1 |
| 37158456 | 2023 | METTL9 derived circular RNA circ-METTL9 sponges miR-551b-5p to accelerate colorectal cancer progression by upregulating CDK6. | 2 |
Citation
Dessen P
CDK6 (cyclin dependent kinase 6)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/321
