REL v-rel reticuloendotheliosis viral oncogene homolog (avian)
2002-01-01 Fei Chen AffiliationHealth Effects Laboratory Division, NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA
DNA/RNA
Description
The gene encoding human Rel has 11 exons spanning ~ 40 kb. The promoter region of rel gene contains five NF-kB binding sites and six Sp1 binding sites, and a number of AP2 sites. Thus, the expression of rel gene might be through autoregulation along with certain stress signals.
Proteins
Expression
wide.
Localisation
cytosol, nuclei after activation.
Function
regulation of the genes involved in cell-to-cell interaction, intercellular communication, cell recruitment or transmigration, amplification or spreading of primary pathogenic signals, cell apoptosis, and initiation or acceleration of tumorigenesis. Interaction with: members of IkB family and Rel family; MKK4; c-Fos; c-Jun; UBE2; PPP4C.
Implicated in
Entity name
cancer, autoimmune arthritis, glomerulonephritis, asthma, inflammatory bowel disease, septic shock, lung fibrosis, HTLV-1 infection, and AIDS.
Oncogenesis
Amplification of rel locus was frequently noted in a number of lymphomas.
Note
Only one report suggested the rearrangement of rel gene in certain type of lymphomas. This rearrangement of rel gene resulted in the deletion of the C-terminal domain of Rel and the fusion of the RHD of Rel with Nrg.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 8717528 | 1996 | The NF-kappa B and I kappa B proteins: new discoveries and insights. | Baldwin AS Jr et al |
| 8281153 | 1993 | Genomic organization of the gene encoding the p65 subunit of NF-kappa B: multiple variants of the p65 protein may be generated by alternative splicing. | Deloukas P et al |
| 9597130 | 1998 | NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. | Ghosh S et al |
| 1650444 | 1991 | Alterations at the rel locus in human lymphoma. | Lu D et al |
| 10602468 | 1999 | Aberrant rel/nfkb genes and activity in human cancer. | Rayet B et al |
| 9660950 | 1998 | Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. | Zhong H et al |
Other Information
Locus ID:
NCBI: 5966
MIM: 164910
HGNC: 9954
Ensembl: ENSG00000162924
Variants:
dbSNP: 5966
ClinVar: 5966
TCGA: ENSG00000162924
COSMIC: REL
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000162924 | ENST00000295025 | Q04864 |
| ENSG00000162924 | ENST00000394479 | Q04864 |
| ENSG00000162924 | ENST00000642725 | A0A2R8Y7Q6 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA33678 | PPP3CA | Gene | Pathway | associated | 23922006 | ||
| PA33679 | PPP3CB | Gene | Pathway | associated | 23922006 | ||
| PA33680 | PPP3CC | Gene | Pathway | associated | 23922006 | ||
| PA33681 | PPP3R1 | Gene | Pathway | associated | 23922006 | ||
| PA33682 | PPP3R2 | Gene | Pathway | associated | 23922006 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35217585 | 2022 | REL and BHLHE40 Variants Are Associated with IL-12 and IL-10 Responses and Tuberculosis Risk. | 4 |
| 35217585 | 2022 | REL and BHLHE40 Variants Are Associated with IL-12 and IL-10 Responses and Tuberculosis Risk. | 4 |
| 33011338 | 2021 | Human galectin-16 has a pseudo ligand binding site and plays a role in regulating c-Rel-mediated lymphocyte activity. | 16 |
| 33484966 | 2021 | METTL3 restrains papillary thyroid cancer progression via m(6)A/c-Rel/IL-8-mediated neutrophil infiltration. | 60 |
| 33995369 | 2021 | NF-κB c-Rel Is Dispensable for the Development but Is Required for the Cytotoxic Function of NK Cells. | 6 |
| 33011338 | 2021 | Human galectin-16 has a pseudo ligand binding site and plays a role in regulating c-Rel-mediated lymphocyte activity. | 16 |
| 33484966 | 2021 | METTL3 restrains papillary thyroid cancer progression via m(6)A/c-Rel/IL-8-mediated neutrophil infiltration. | 60 |
| 33995369 | 2021 | NF-κB c-Rel Is Dispensable for the Development but Is Required for the Cytotoxic Function of NK Cells. | 6 |
| 31768922 | 2020 | Constitutive expression of c-REL in uveal melanoma patients: correlation with clinicopathological parameters and patient outcome. | 2 |
| 31986466 | 2020 | Pro-survival and anti-inflammatory roles of NF-κB c-Rel in the Parkinson's disease models. | 19 |
| 32282963 | 2020 | Association study between vitiligo and autoimmune-related genes CYP27B1, REL, TNFAIP3, IL2 and IL21. | 3 |
| 32331232 | 2020 | A Matter of Choice: Inhibition of c-Rel Shifts Neuronal to Oligodendroglial Fate in Human Stem Cells. | 8 |
| 32659596 | 2020 | The c-Rel-c-Myc axis controls metabolism and proliferation of human T leukemia cells. | 3 |
| 31768922 | 2020 | Constitutive expression of c-REL in uveal melanoma patients: correlation with clinicopathological parameters and patient outcome. | 2 |
| 31986466 | 2020 | Pro-survival and anti-inflammatory roles of NF-κB c-Rel in the Parkinson's disease models. | 19 |
Citation
Fei Chen
REL v-rel reticuloendotheliosis viral oncogene homolog (avian)
Atlas Genet Cytogenet Oncol Haematol. 2002-01-01
Online version: http://atlasgeneticsoncology.org/gene/322
