RELB (v-rel reticuloendotheliosis viral oncogene homolog B)
2002-01-01 Fei Chen AffiliationHealth Effects Laboratory Division, NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA
Identity
HGNC
LOCATION
19q13.32
LOCUSID
ALIAS
I-REL,IMD53,IREL,REL-B
FUSION GENES
DNA/RNA
Description
The gene encoding human RelB has 11 exons spanning ~ 37 kb. Analysis of the 5-flanking region of human relb gene indicates that RelB transcription is dependent on a TATA-less promoter containing two kB sites. Thus, while relA is constitutively expressed, the expression of both rel and relb is in an inducible fashion and dependent on NF-kB.
Proteins
Expression
wide.
Localisation
cytosol, nuclei after activation.
Function
regulation of the genes involved in cell-to-cell interaction, intercellular communication, cell recruitment or transmigration, amplification or spreading of primary pathogenic signals, cell apoptosis, and initiation or acceleration of tumorigenesis. Interaction with: members of IkB family and Rel family.
Implicated in
Entity name
cancer, autoimmune arthritis, glomerulonephritis, asthma, inflammatory bowel disease, septic shock, lung fibrosis, HTLV-1 infection, and AIDS.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 8717528 | 1996 | The NF-kappa B and I kappa B proteins: new discoveries and insights. | Baldwin AS Jr et al |
| 8183565 | 1994 | Human RelB (I-Rel) functions as a kappa B site-dependent transactivating member of the family of Rel-related proteins. | Bours V et al |
| 9597130 | 1998 | NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. | Ghosh S et al |
| 1577270 | 1992 | I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity. | Ruben SM et al |
Other Information
Locus ID:
NCBI: 5971
MIM: 604758
HGNC: 9956
Ensembl: ENSG00000104856
Variants:
dbSNP: 5971
ClinVar: 5971
TCGA: ENSG00000104856
COSMIC: RELB
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA33678 | PPP3CA | Gene | Pathway | associated | 23922006 | ||
| PA33679 | PPP3CB | Gene | Pathway | associated | 23922006 | ||
| PA33680 | PPP3CC | Gene | Pathway | associated | 23922006 | ||
| PA33681 | PPP3R1 | Gene | Pathway | associated | 23922006 | ||
| PA33682 | PPP3R2 | Gene | Pathway | associated | 23922006 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36402602 | 2023 | NFκB pathway dysregulation due to reduced RelB expression leads to severe autoimmune disorders and declining immunity. | 4 |
| 36863451 | 2023 | RelB represses miR-193a-5p expression to promote the phenotypic transformation of vascular smooth muscle cells in aortic aneurysm. | 0 |
| 37175530 | 2023 | NF-κB Signaling Modulates miR-452-5p and miR-335-5p Expression to Functionally Decrease Epithelial Ovarian Cancer Progression in Tumor-Initiating Cells. | 1 |
| 38139378 | 2023 | Inflammation in Hypervolemic Hemodialysis Patients: The Roles of RelB and Caspase-4. | 1 |
| 36402602 | 2023 | NFκB pathway dysregulation due to reduced RelB expression leads to severe autoimmune disorders and declining immunity. | 4 |
| 36863451 | 2023 | RelB represses miR-193a-5p expression to promote the phenotypic transformation of vascular smooth muscle cells in aortic aneurysm. | 0 |
| 37175530 | 2023 | NF-κB Signaling Modulates miR-452-5p and miR-335-5p Expression to Functionally Decrease Epithelial Ovarian Cancer Progression in Tumor-Initiating Cells. | 1 |
| 38139378 | 2023 | Inflammation in Hypervolemic Hemodialysis Patients: The Roles of RelB and Caspase-4. | 1 |
| 34232979 | 2022 | The alternative RelB NF-κB subunit is a novel critical player in diffuse large B-cell lymphoma. | 20 |
| 34933092 | 2022 | RelB promotes the migration and invasion of prostate cancer DU145 cells via exosomal ICAM1 in vitro. | 7 |
| 36110848 | 2022 | RelB contributes to the survival, migration and lymphomagenesis of B cells with constitutively active CD40 signaling. | 2 |
| 34232979 | 2022 | The alternative RelB NF-κB subunit is a novel critical player in diffuse large B-cell lymphoma. | 20 |
| 34933092 | 2022 | RelB promotes the migration and invasion of prostate cancer DU145 cells via exosomal ICAM1 in vitro. | 7 |
| 36110848 | 2022 | RelB contributes to the survival, migration and lymphomagenesis of B cells with constitutively active CD40 signaling. | 2 |
| 34047463 | 2021 | Serum RelB is correlated with renal fibrosis and predicts chronic kidney disease progression. | 2 |
Citation
Fei Chen
RELB (v-rel reticuloendotheliosis viral oncogene homolog B)
Atlas Genet Cytogenet Oncol Haematol. 2002-01-01
Online version: http://atlasgeneticsoncology.org/gene/324/relb-(v-rel-reticuloendotheliosis-viral-oncogene-homolog-b)
