RELA (v-rel reticuloendotheliosis viral oncogene homolog A (avian))
2002-01-01 Fei Chen AffiliationHealth Effects Laboratory Division, NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA
Identity
HGNC
LOCATION
11q13.1
IMAGE
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
CMCU,NFKB3,p65
FUSION GENES
DNA/RNA
Description
The gene encoding human RelA has 10 exons spanning 8.1 kb. The shorter variants of RelA (p65d) can be generated by alternative splicing of intron 1, 6, or 7. The p65d1 lacks codons for amino acids 222 to 231 and p65d2 lacks codons for amino acids 13 to 25 of the conserved Rel homology domain. An additional alternative splicing form of p65, p65d3 has been identified in a non-small-cell lung carcinoma cell line that lacks codons for amino acids 187 to 293 of the Rel homology domain.
Proteins
Expression
wide.
Localisation
cytosol, nuclei after activation.
Function
regulation of the genes involved in cell-to-cell interaction, intercellular communication, cell recruitment or transmigration, amplification or spreading of primary pathogenic signals, cell apoptosis, and initiation or acceleration of tumorigenesis. The p50/RelA complex is the most abundant NF-kB complex in all type tissues or cells. Interaction with: members of IkB family and Rel family; GR; HDAC3; CREB; p300; Sp1, Egr1; AES; TFIIB.
Implicated in
Entity name
cancer, autoimmune arthritis, glomerulonephritis, asthma, inflammatory bowel disease, septic shock, lung fibrosis, HTLV-1 infection, and AIDS.
Oncogenesis
Chromosomal rearrangement or point mutation of relA gene has been implicated infrequently in human lymphoid tumors. A t(11;14)(q14;q32?) chromosomal translocation was described in 4 cases of lymphoproliferative disorders (LPD), which possibly involved p65 gene rearrangement. Gene amplification or increased expression of relA has also been noted in some cases of squamous carcinomas of head and neck, and in adenocarcinomas of breast and stomach.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 8717528 | 1996 | The NF-kappa B and I kappa B proteins: new discoveries and insights. | Baldwin AS Jr et al |
| 8281153 | 1993 | Genomic organization of the gene encoding the p65 subunit of NF-kappa B: multiple variants of the p65 protein may be generated by alternative splicing. | Deloukas P et al |
| 9597130 | 1998 | NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. | Ghosh S et al |
| 10602468 | 1999 | Aberrant rel/nfkb genes and activity in human cancer. | Rayet B et al |
| 582293 | 1979 | A new characteristic karyotypic anomaly in lymphoproliferative disorders. | Van Den Berghe H et al |
| 9660950 | 1998 | Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. | Zhong H et al |
Other Information
Locus ID:
NCBI: 5970
MIM: 164014
HGNC: 9955
Ensembl: ENSG00000173039
Variants:
dbSNP: 5970
ClinVar: 5970
TCGA: ENSG00000173039
COSMIC: RELA
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA131301952 | gefitinib | Chemical | ClinicalAnnotation | associated | PD | 31664190 | |
| PA134992438 | CAMK1D | Gene | Pathway | associated | |||
| PA164925725 | Toxic liver disease | Disease | ClinicalAnnotation | associated | PD | 31664190 | |
| PA24684 | AKT1 | Gene | Pathway | associated | |||
| PA24685 | AKT2 | Gene | Pathway | associated | |||
| PA24686 | AKT3 | Gene | Pathway | associated | |||
| PA26048 | CAMK1 | Gene | Pathway | associated | |||
| PA26049 | CAMK1G | Gene | Pathway | associated | |||
| PA283 | MAPK8 | Gene | Pathway | associated | |||
| PA30616 | MAPK1 | Gene | Pathway | associated | |||
| PA30622 | MAPK3 | Gene | Pathway | associated | |||
| PA33678 | PPP3CA | Gene | Pathway | associated | 23922006 | ||
| PA33679 | PPP3CB | Gene | Pathway | associated | 23922006 | ||
| PA33680 | PPP3CC | Gene | Pathway | associated | 23922006 | ||
| PA33681 | PPP3R1 | Gene | Pathway | associated | 23922006 | ||
| PA33682 | PPP3R2 | Gene | Pathway | associated | 23922006 | ||
| PA337 | STAT3 | Gene | Pathway | associated | |||
| PA33759 | PRKCA | Gene | Pathway | associated | |||
| PA33761 | PRKCB | Gene | Pathway | associated | |||
| PA33766 | PRKCG | Gene | Pathway | associated | |||
| PA338 | STAT5A | Gene | Pathway | associated | |||
| PA36183 | STAT1 | Gene | Pathway | associated | |||
| PA36184 | STAT2 | Gene | Pathway | associated | |||
| PA36185 | STAT4 | Gene | Pathway | associated | |||
| PA36186 | STAT5B | Gene | Pathway | associated | |||
| PA443622 | Carcinoma, Non-Small-Cell Lung | Disease | ClinicalAnnotation | associated | PD | 31664190 | |
| PA444552 | Hypertension | Disease | Literature, MultilinkAnnotation | associated | 24560520 | ||
| PA90 | CAMK2A | Gene | Pathway | associated | |||
| PA91 | CAMK2B | Gene | Pathway | associated | |||
| PA92 | CAMK2D | Gene | Pathway | associated | |||
| PA93 | CAMK2G | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37454278 | 2024 | LAMB3 Promotes Intestinal Inflammation Through SERPINA3 and Is Directly Transcriptionally Regulated by P65 in Inflammatory Bowel Disease. | 1 |
| 37730133 | 2024 | Interplay between SUMO1-related SUMOylation and phosphorylation of p65 promotes hepatocellular carcinoma progression. | 3 |
| 37856812 | 2024 | Tumor Necrosis Factor Alpha-Induced Protein-3 Inhibits the Activation of Hepatic Stellate Cells by Regulating the p65 Molecule in the NF-κB Signaling Pathway. | 0 |
| 37980653 | 2024 | Renal ischaemia-reperfusion injury is promoted by transcription factor NF-kB p65, which inhibits TRPC6 expression by activating miR-150. | 0 |
| 38284203 | 2024 | Insulin-like growth factor 2 mRNA-binding protein 3 enhanced melanoma migration through regulation of AKT1 and RELA expression. | 0 |
| 38360128 | 2024 | Silent information regulator 2 deficiency exacerbates chronic cold exposure-induced colonic injury and p65 activation in mice. | 0 |
| 38367599 | 2024 | Transcription factor RELA promotes hepatocellular carcinoma progression by promoting the transcription of m6A modulator METTL3. | 0 |
| 38452206 | 2024 | WSB1/2 target chromatin-bound lysine-methylated RelA for proteasomal degradation and NF-κB termination. | 0 |
| 38473959 | 2024 | The Prolonged Activation of the p65 Subunit of the NF-Kappa-B Nuclear Factor Sustains the Persistent Effect of Advanced Glycation End Products on Inflammatory Sensitization in Macrophages. | 1 |
| 38504985 | 2024 | The NF-κB RelA transcription factor is not required for CD8+ T-cell function in acute viral infection and cancer. | 0 |
| 38514058 | 2024 | Role of NF-κB p65/TNF-α in Cell Apoptosis in the Fetal Membranes of Pregnant Women with Preterm Premature Rupture of Membranes. | 0 |
| 38612387 | 2024 | A1CF Binding to the p65 Interaction Site on NKRF Decreased IFN-β Expression and p65 Phosphorylation (Ser536) in Renal Carcinoma Cells. | 0 |
| 37454278 | 2024 | LAMB3 Promotes Intestinal Inflammation Through SERPINA3 and Is Directly Transcriptionally Regulated by P65 in Inflammatory Bowel Disease. | 1 |
| 37730133 | 2024 | Interplay between SUMO1-related SUMOylation and phosphorylation of p65 promotes hepatocellular carcinoma progression. | 3 |
| 37856812 | 2024 | Tumor Necrosis Factor Alpha-Induced Protein-3 Inhibits the Activation of Hepatic Stellate Cells by Regulating the p65 Molecule in the NF-κB Signaling Pathway. | 0 |
Citation
Fei Chen
RELA (v-rel reticuloendotheliosis viral oncogene homolog A (avian))
Atlas Genet Cytogenet Oncol Haematol. 2002-01-01
Online version: http://atlasgeneticsoncology.org/gene/325
