GHRL (ghrelin/obestatin prepropeptide)
2001-03-01 Catherine Tomasetto AffiliationI.G.B.M.C., BP 163, 1 rue Laurent Fries, 67404 Illkirch, France
Identity
HGNC
LOCATION
3p25.3
IMAGE
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
MTLRP
DNA/RNA
Transcription
600 bp, two mRNAs are encoded by the same genes, they are identical except for the lack of one codon (CAG) located at an exon intron boundary.
Proteins
Description
Expression
Ghrelin/MTLRP is mainly expressed by the enteroendocrine cells of the stomach; its expression decreased gradually along the gastro-intestinal tract and a faint expression was also detected in testis. By Immnunochemistry Ghrelin-immuno reactive neurons were found in the hypothalamic arcuate nucleus.
Localisation
As a peptide hormone Ghrelin/MTLRP is secreted in the blood.
Function
As the endogenous ligand of the growth hormone secretagogues (GHS) receptor, Ghrelin/MTLRP is involved in the pulsatile secretion of Growth hormone. In addition to this role Ghrelin/MTLRP is in the regulation of feeding. In rodent In contrast to leptin, Ghrelin/MTLRP promotes food intake and obesity. In addition Ghrelin/MTLRP stimulates motricity of the gastrointestinal tract and acid secretion.
Homology
ppGhrelin/MTLRP share 47% of similarity with the precursor of Motilin. In addition Ghrelin receptor (GHS-R) and Motilin receptor (GPR38) share 52% identity.
Implicated in
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 10801861 | 2000 | Purification and characterization of rat des-Gln14-Ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor. | Hosoda H et al |
| 10604470 | 1999 | Ghrelin is a growth-hormone-releasing acylated peptide from stomach. | Kojima M et al |
| 11027567 | 2000 | Ghrelin stimulates gastric acid secretion and motility in rats. | Masuda Y et al |
| 11196643 | 2001 | A role for ghrelin in the central regulation of feeding. | Nakazato M et al |
| 10930375 | 2000 | Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide. | Tomasetto C et al |
| 11057670 | 2000 | Ghrelin induces adiposity in rodents. | Tschöp M et al |
| 11089570 | 2000 | The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. | Wren AM et al |
Other Information
Locus ID:
NCBI: 51738
MIM: 605353
HGNC: 18129
Ensembl: ENSG00000157017
Variants:
dbSNP: 51738
ClinVar: 51738
TCGA: ENSG00000157017
COSMIC: GHRL
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406954 | Weight gain | Disease | MultilinkAnnotation | associated | 24279860 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32921167 | 2023 | Ghrelin intronic lncRNAs, lnc-GHRL-3:2 and lnc-GHRL-3:3, as novel biomarkers in type 2 diabetes mellitus. | 2 |
| 36543283 | 2023 | Ghrelin proteolysis increases in plasma of men, but not women, with obesity. | 0 |
| 36740132 | 2023 | How gut hormones shape reward: A systematic review of the role of ghrelin and GLP-1 in human fMRI. | 6 |
| 37237241 | 2023 | LNX2 involves in the role of ghrelin to promote the neuronal differentiation of adipose tissue-derived mesenchymal stem cells. | 0 |
| 37715984 | 2023 | Effect of the GHRL gene (rs696217) polymorphism on the metabolic disorders in patients with obesity in the Ukrainian population. | 0 |
| 37735188 | 2023 | Ameliorative effects of aerobic training in girls with precocious puberty: role of leptin and ghrelin. | 1 |
| 38127688 | 2023 | GHRL, LEP, LEPR genes polymorphism and their association with the metabolic syndrome in the Ukrainian population. | 0 |
| 32921167 | 2023 | Ghrelin intronic lncRNAs, lnc-GHRL-3:2 and lnc-GHRL-3:3, as novel biomarkers in type 2 diabetes mellitus. | 2 |
| 36543283 | 2023 | Ghrelin proteolysis increases in plasma of men, but not women, with obesity. | 0 |
| 36740132 | 2023 | How gut hormones shape reward: A systematic review of the role of ghrelin and GLP-1 in human fMRI. | 6 |
| 37237241 | 2023 | LNX2 involves in the role of ghrelin to promote the neuronal differentiation of adipose tissue-derived mesenchymal stem cells. | 0 |
| 37715984 | 2023 | Effect of the GHRL gene (rs696217) polymorphism on the metabolic disorders in patients with obesity in the Ukrainian population. | 0 |
| 37735188 | 2023 | Ameliorative effects of aerobic training in girls with precocious puberty: role of leptin and ghrelin. | 1 |
| 38127688 | 2023 | GHRL, LEP, LEPR genes polymorphism and their association with the metabolic syndrome in the Ukrainian population. | 0 |
| 33373270 | 2022 | Ghrelin as a prominent endocrine factor in stress-induced obesity. | 4 |
Citation
Catherine Tomasetto
GHRL (ghrelin/obestatin prepropeptide)
Atlas Genet Cytogenet Oncol Haematol. 2001-03-01
Online version: http://atlasgeneticsoncology.org/gene/327/ghrl-(ghrelin-obestatin-prepropeptide)
