Identity
HGNC
LOCATION
8q11.21
LOCUSID
ALIAS
DNA-PKC,DNA-PKcs,DNAPK,DNAPKc,DNPK1,HYRC,HYRC1,IMD26,XRCC7,p350
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5591
MIM: 600899
HGNC: 9413
Ensembl: ENSG00000253729
Variants:
dbSNP: 5591
ClinVar: 5591
TCGA: ENSG00000253729
COSMIC: PRKDC
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000253729 | ENST00000314191 | P78527 |
| ENSG00000253729 | ENST00000338368 | P78527 |
| ENSG00000253729 | ENST00000536429 | H0YG84 |
| ENSG00000253729 | ENST00000540819 | F5GX40 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA29116 | H2AFX | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38216092 | 2024 | Identification of MCM4 and PRKDC as new regulators of osteosarcoma cell dormancy based on 3D cell cultures. | 1 |
| 38407308 | 2024 | DNA-PK controls Apollo's access to leading-end telomeres. | 1 |
| 38412274 | 2024 | DNA-PKcs suppresses illegitimate chromosome rearrangements. | 1 |
| 38732044 | 2024 | PRKDC-Mediated NHEJ May Play a Crucial Role in Aneuploidy of Chromosome 8-Driven Progression of Ovarian Cancer. | 0 |
| 38216092 | 2024 | Identification of MCM4 and PRKDC as new regulators of osteosarcoma cell dormancy based on 3D cell cultures. | 1 |
| 38407308 | 2024 | DNA-PK controls Apollo's access to leading-end telomeres. | 1 |
| 38412274 | 2024 | DNA-PKcs suppresses illegitimate chromosome rearrangements. | 1 |
| 38732044 | 2024 | PRKDC-Mediated NHEJ May Play a Crucial Role in Aneuploidy of Chromosome 8-Driven Progression of Ovarian Cancer. | 0 |
| 36494579 | 2023 | FAP is critical for ovarian cancer cell survival by sustaining NF-κB activation through recruitment of PRKDC in lipid rafts. | 4 |
| 36574362 | 2023 | DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma. | 9 |
| 36707503 | 2023 | DNA-PK hyperactivation occurs in deletion 11q chronic lymphocytic leukemia and is both a biomarker and therapeutic target for drug-resistant disease. | 0 |
| 36727301 | 2023 | DNA-PKcs and ATM modulate mitochondrial ADP-ATP exchange as an oxidative stress checkpoint mechanism. | 7 |
| 37002788 | 2023 | Up-regulation of PRKDC was associated with poor renal dysfunction after renal transplantation: A multi-centre analysis. | 1 |
| 37149747 | 2023 | Chemical inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4(+) helper and CD8(+) effector T cells. | 2 |
| 36494579 | 2023 | FAP is critical for ovarian cancer cell survival by sustaining NF-κB activation through recruitment of PRKDC in lipid rafts. | 4 |
Citation
Dessen P
PRKDC (protein kinase, DNA-activated, catalytic subunit)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/338/prkdc-(protein-kinase-dna-activated-catalytic-subunit)
