TPM4 (tropomyosin)

2001-08-01   Jean-Loup Huret  

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
TPM4
LOCATION
19p13.12
LOCUSID
7171
ALIAS
HEL-S-108
FUSION GENES
Show Gene Fusions

DNA/RNA

Transcription

alternate transcripts

Proteins

Description

248 amino acids, 29 kDa. Coiled-coil structure

Function

Tropomyosins are actin-binding proteins; component of cytoskeletal microfilaments; tropomyosins mediate the effect of Ca2+ on the myosin-actin interaction In skeletal muscles, but their function in smooth muscles and other tissues is yet unknown

Homology

Other tropomyosins: TPM1 (alpha) located in 15q22, TPM2 (beta), located in 9q13, and TPM3 located in 1q25

Implicated in

Entity name
Inflammatory myofibroblastic tumors with t(2;19)(p23;p13.1)
Disease
rare soft tissue tumour found in children and young adults
Prognosis
good prognosis
Hybrid gene
5 CLTC - 3 ALK
Fusion protein
221 N-term amino acids from TPM4 fused to the 562 C-term amino acids from ALK (i.e. the entire cytoplasmic portion of ALK with the tyrosine kinase domain); homodimerization of the fusion protein.
Oncogenesis
TPM4-ALK is contitutively activated

Article Bibliography

Pubmed IDLast YearTitleAuthors
114386842001Deciphering the design of the tropomyosin molecule.Brown JH et al
103831291999Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors.Griffin CA et al
109341372000Aberrant ALK tyrosine kinase signaling. Different cellular lineages, common oncogenic mechanisms.Ladanyi M et al
109341422000TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors.Lawrence B et al
109861212000Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments.Lehman W et al

Other Information

Locus ID:

NCBI: 7171
MIM: 600317
HGNC: 12013
Ensembl: ENSG00000167460

Variants:

dbSNP: 7171
ClinVar: 7171
TCGA: ENSG00000167460
COSMIC: TPM4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167460ENST00000586499K7ERG3
ENSG00000167460ENST00000586833K7ENT6
ENSG00000167460ENST00000588032K7EPB9
ENSG00000167460ENST00000589897K7ELP0
ENSG00000167460ENST00000642221A0A2R8YE05
ENSG00000167460ENST00000642789A0A2R8YEU4
ENSG00000167460ENST00000643494A0A2R8YGX3
ENSG00000167460ENST00000643579P67936
ENSG00000167460ENST00000643579V9HW56
ENSG00000167460ENST00000645471A0A2R8Y5V9
ENSG00000167460ENST00000646575A0A2R8YH90
ENSG00000167460ENST00000646974P67936
ENSG00000167460ENST00000647037A0A2R8Y5V9
ENSG00000167460ENST00000647464A0A2R8YHD2
ENSG00000167460ENST00000653979A0A590UKD0
ENSG00000167460ENST00000659595A0A590UK79
ENSG00000167460ENST00000670382A0A590UJB9

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cardiac muscle contractionKEGGhsa04260
Cardiac muscle contractionKEGGko04260
Hypertrophic cardiomyopathy (HCM)KEGGko05410
Hypertrophic cardiomyopathy (HCM)KEGGhsa05410
Dilated cardiomyopathyKEGGko05414
Dilated cardiomyopathyKEGGhsa05414
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
Muscle contractionREACTOMER-HSA-397014
Striated Muscle ContractionREACTOMER-HSA-390522
Smooth Muscle ContractionREACTOMER-HSA-445355

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
369939582023Integrated pan-cancer analysis and experimental verification of the roles of tropomyosin 4 in gastric cancer.6
373287952023MicroRNA-5195-3p mediated malignant biological behaviour of insulin-resistant liver cancer cells via SOX9 and TPM4.0
369939582023Integrated pan-cancer analysis and experimental verification of the roles of tropomyosin 4 in gastric cancer.6
373287952023MicroRNA-5195-3p mediated malignant biological behaviour of insulin-resistant liver cancer cells via SOX9 and TPM4.0
347581892022Rare missense variants in Tropomyosin-4 (TPM4) are associated with platelet dysfunction, cytoskeletal defects, and excessive bleeding.2
363444952022LncRNA SFTA1P promotes cervical cancer progression by interaction with PTBP1 to facilitate TPM4 mRNA degradation.5
347581892022Rare missense variants in Tropomyosin-4 (TPM4) are associated with platelet dysfunction, cytoskeletal defects, and excessive bleeding.2
363444952022LncRNA SFTA1P promotes cervical cancer progression by interaction with PTBP1 to facilitate TPM4 mRNA degradation.5
333907852021The expression and clinical significance of TPM4 in hepatocellular carcinoma.11
345759792021The miR-133a, TPM4 and TAp63γ Role in Myocyte Differentiation Microfilament Remodelling and Colon Cancer Progression.5
333907852021The expression and clinical significance of TPM4 in hepatocellular carcinoma.11
345759792021The miR-133a, TPM4 and TAp63γ Role in Myocyte Differentiation Microfilament Remodelling and Colon Cancer Progression.5
323636172020Differential expression and diagnostic significance of P53, MutS homologs 2, tropomyosin-4 in alpha-fetoprotein-negative hepatocellular carcinoma.2
324327392020TPM4 aggravates the malignant progression of hepatocellular carcinoma through negatively regulating SUSD2.7
323636172020Differential expression and diagnostic significance of P53, MutS homologs 2, tropomyosin-4 in alpha-fetoprotein-negative hepatocellular carcinoma.2

Citation

Jean-Loup Huret

TPM4 (tropomyosin)

Atlas Genet Cytogenet Oncol Haematol. 2001-08-01

Online version: http://atlasgeneticsoncology.org/gene/359