MSN (moesin)
2001-08-01 Jean-Loup Huret AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Identity
HGNC
LOCATION
Xq12
IMAGE
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
moesin (membrane-organising extension spike protein)
FUSION GENES
DNA/RNA
Transcription
3879 bp mRNA with a 1733 bp of coding sequence
Proteins
Description
576 amino acids, 75 kDa; contains in N-term a globular membrane binding domain (band 4.1 like domain (amino acids 57 to 224), known also as the four-point-one/ezrin/radixin/moesin domai, an alpha helix domain, and in C-term a domain which interact with actin filaments
Expression
wide; expressed differentially in microvilli and cell adhesion sites
Function
cytoskeleton protein; binds to the plasma membrane and interacts with actin/myosin; role in cell-cell recognition and signaling
Homology
Ezrin, radixin, moesin are called the ERM proteins; they are members ofthe band 4.1 superfamily
Implicated in
Entity name
Disease
found in a case of ALK+ anaplasic large cell lymphoma
Fusion protein
1005 amino acids, 125 kDa; membrane restricted; ;448 N-term amino acid from MSN, containing the band 4.1 like domain and most of the alpha helix domain, fused to the 557 (instead of the usual 562) C-term amino acids from ALK (i.e. the cytoplasmic portion of ALK with the tyrosine kinase domain).
Oncogenesis
tyrosine kinase activity.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 8227193 | 1993 | Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells. | Berryman M et al |
| 10047517 | 1999 | Regulation of cortical structure by the ezrin-radixin-moesin protein family. | Bretscher A et al |
| 9757824 | 1998 | The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane. | Chishti AH et al |
| 1924289 | 1991 | Moesin: a member of the protein 4.1-talin-ezrin family of proteins. | Lankes WT et al |
| 10322453 | 1999 | ERM proteins in cell adhesion and membrane dynamics. | Mangeat P et al |
| 11310834 | 2001 | Molecular characterization of a new ALK translocation involving moesin (MSN-ALK) in anaplastic large cell lymphoma. | Tort F et al |
| 10574907 | 1999 | Cortical actin organization: lessons from ERM (ezrin/radixin/moesin) proteins. | Tsukita S et al |
Other Information
Locus ID:
NCBI: 4478
MIM: 309845
HGNC: 7373
Ensembl: ENSG00000147065
Variants:
dbSNP: 4478
ClinVar: 4478
TCGA: ENSG00000147065
COSMIC: MSN
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000147065 | ENST00000360270 | P26038 |
| ENSG00000147065 | ENST00000360270 | V9HWC0 |
| ENSG00000147065 | ENST00000609672 | V9GZ54 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38052292 | 2024 | Two cases of pediatric primary immunodeficiency caused by a familial moesin(MSN)gene mutation. | 0 |
| 38141516 | 2024 | Moesin affects the plasma membrane expression and the immune checkpoint function of CD47 in human ovarian clear cell carcinoma. | 0 |
| 38267973 | 2024 | The role of moesin in diagnosing and assessing severity of lymphangioleiomyomatosis. | 0 |
| 38052292 | 2024 | Two cases of pediatric primary immunodeficiency caused by a familial moesin(MSN)gene mutation. | 0 |
| 38141516 | 2024 | Moesin affects the plasma membrane expression and the immune checkpoint function of CD47 in human ovarian clear cell carcinoma. | 0 |
| 38267973 | 2024 | The role of moesin in diagnosing and assessing severity of lymphangioleiomyomatosis. | 0 |
| 34785348 | 2022 | Role of moesin in the effect of glucagon-like peptide-1 on advanced glycation end products-induced endothelial barrier dysfunction. | 2 |
| 35718975 | 2022 | Identification of Neural Progenitor Cell-associated Chemoradiotherapy Resistance Gene Set (ARL4C, MSN, TNFAIP6) for Prognosis of Glioma. | 2 |
| 36119109 | 2022 | Hemizygous nonsense variant in the moesin gene (MSN) leads to a new autoimmune phenotype of Immunodeficiency 50. | 3 |
| 34785348 | 2022 | Role of moesin in the effect of glucagon-like peptide-1 on advanced glycation end products-induced endothelial barrier dysfunction. | 2 |
| 35718975 | 2022 | Identification of Neural Progenitor Cell-associated Chemoradiotherapy Resistance Gene Set (ARL4C, MSN, TNFAIP6) for Prognosis of Glioma. | 2 |
| 36119109 | 2022 | Hemizygous nonsense variant in the moesin gene (MSN) leads to a new autoimmune phenotype of Immunodeficiency 50. | 3 |
| 33628853 | 2021 | Moesin Is a Novel Biomarker of Endothelial Injury in Sepsis. | 5 |
| 33838692 | 2021 | Moesin as a prognostic indicator of lung adenocarcinoma improves prognosis by enhancing immune lymphocyte infiltration. | 12 |
| 34603794 | 2021 | Activation of TMEM16A Ca(2+)-activated Cl(-) channels by ROCK1/moesin promotes breast cancer metastasis. | 12 |
Citation
Jean-Loup Huret
MSN (moesin)
Atlas Genet Cytogenet Oncol Haematol. 2001-08-01
Online version: http://atlasgeneticsoncology.org/gene/363
