CTTN (cortactin)

2003-02-01  

Identity

HGNC
CTTN
LOCATION
11q13.3
LOCUSID
2017
ALIAS
EMS1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2017
MIM: 164765
HGNC: 3338
Ensembl: ENSG00000085733

Variants:

dbSNP: 2017
ClinVar: 2017
TCGA: ENSG00000085733
COSMIC: CTTN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000085733ENST00000301843Q14247
ENSG00000085733ENST00000346329Q14247
ENSG00000085733ENST00000346329A0A024R5M3
ENSG00000085733ENST00000376561Q14247
ENSG00000085733ENST00000529736H0YCD9
ENSG00000085733ENST00000533931H0YEV2

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Pathogenic Escherichia coli infectionKEGGko05130
Tight junctionKEGGhsa04530
Pathogenic Escherichia coli infectionKEGGhsa05130
ShigellosisKEGGhsa05131
Bacterial invasion of epithelial cellsKEGGko05100
Bacterial invasion of epithelial cellsKEGGhsa05100
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate PAKsREACTOMER-HSA-5627123
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381261702024Requirement of Site-Specific Tyrosine Phosphorylation of Cortactin in Retinal Neovascularization and Vascular Leakage.0
383536962024A MAP1B-cortactin-Tks5 axis regulates TNBC invasion and tumorigenesis.1
383588952024METTL3 promotes osteogenic differentiation of human umbilical cord mesenchymal stem cells by up-regulating m6A modification of circCTTN.0
381261702024Requirement of Site-Specific Tyrosine Phosphorylation of Cortactin in Retinal Neovascularization and Vascular Leakage.0
383536962024A MAP1B-cortactin-Tks5 axis regulates TNBC invasion and tumorigenesis.1
383588952024METTL3 promotes osteogenic differentiation of human umbilical cord mesenchymal stem cells by up-regulating m6A modification of circCTTN.0
367901392023Cortactin expression in a Norwegian cohort of human papilloma virus negative oral squamous cell carcinomas of the mobile tongue.1
370398232023Binding of USP4 to cortactin enhances cell migration in HCT116 human colon cancer cells.0
367901392023Cortactin expression in a Norwegian cohort of human papilloma virus negative oral squamous cell carcinomas of the mobile tongue.1
370398232023Binding of USP4 to cortactin enhances cell migration in HCT116 human colon cancer cells.0
345336702022Cortactin and HER2 as potential markers for dural-targeted therapy in advanced gastric cancer.2
351815492022A cortactin CTTN coding SNP contributes to lung vascular permeability and inflammatory disease severity in African descent subjects.5
353168772022[The expression of cortactin in colorectal cancer and its relationship with clinicopathological and prognostic parameters].0
360439962022CBLC inhibits the proliferation and metastasis of breast cancer cells via ubiquitination and degradation of CTTN.1
345336702022Cortactin and HER2 as potential markers for dural-targeted therapy in advanced gastric cancer.2

Citation

Dessen P

CTTN (cortactin)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/369/cttn-(cortactin)