ZBTB16 (zinc finger and BTB domain containing 16)
1998-04-01 Franck Viguié AffiliationLaboratoire de Cytogenetique - Service dHematologie Biologique, Hopital Hotel-Dieu - 75181 Paris Cedex 04, France
DNA/RNA
c-PLZF at 11q23.1 in normal cells: PAC 980J15 - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
Transcription
2.2 kb mRNA; alternative splicing: --> PLZFa and PLZFb
Proteins
Description
540 and 673 amino acids, 62 and 74 kDa (PLZFa and b
respectively); Kr¸ppel-like zinc finger protein; N-term BTB/POZ domain
(protein-protein interaction motif) and 9 zinc finger domains in C-term
Expression
highly specific for hematopoietic cells; during mouse
development, PLZF is expressed in embryonic tissus, giving rise to
hematopoietic progenitors; in man, PLZF is expressed in CD34+ progenitor
cells and in primitive multipotent hematopoietic cell lines; PLZF levels
decrease progressively with cell maturation and also with maturation
induced by ATRA treatment.
Localisation
nuclear; immunodetection shows a nuclear speckeled
distribution of PLZF, resulting from a localization on discrete nuclear
bodies whose formation is dependent on the integrity of the BTB/POZ
domain.
Function
putative transcription factor associated with myeloid
differentiation; sequence specific DNA binding activity; in co-transfection
experiments, PLZF has been shown to represses the transcription.
Homology
with the zinc finger MZF-1
Implicated in
Disease
acute promyelocytic leukaemia with a variant translocation
Prognosis
worse prognosis than M3 AML with t(15;17), because the patients
fail to respond to the maturation effect of ATRA
Cytogenetics
t(11;17), like t(15;17)(q22;q21), and like another
t(11;17)(q13;q21), with a discrete breakpoint in 11q13 are,
closely related to t(15;17)(q22;q21)
Hybrid gene
both fusion transcripts are expressed
Fusion protein
the two fusion proteins are produced; the PLZF/RARa protein
contains the N-terminal BTB/POZ domain and two out of the nine zinc finger
domains from PLZF; tThe POZ domain is largely responsible for the activity of PLZF/RARa fusion protein.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 8387545 | 1993 | Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia. | Chen SJ et al |
| 9294197 | 1997 | Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies. | Koken MH et al |
| 8570209 | 1996 | Reduced and altered DNA-binding and transcriptional properties of the PLZF-retinoic acid receptor-alpha chimera generated in t(11;17)-associated acute promyelocytic leukemia. | Licht JD et al |
| 8952164 | 1996 | PML, PLZF and NPM genes in the molecular pathogenesis of acute promyelocytic leukemia. | Pandolfi PP et al |
Other Information
Locus ID:
NCBI: 7704
MIM: 176797
HGNC: 12930
Ensembl: ENSG00000109906
Variants:
dbSNP: 7704
ClinVar: 7704
TCGA: ENSG00000109906
COSMIC: ZBTB16
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38245954 | 2024 | Investigating the association of previously identified genome-wide significant loci (rs10739076 and rs1784692) with PCOS susceptibility and its related traits in Indian women. | 0 |
| 38287116 | 2024 | Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis. | 2 |
| 38373386 | 2024 | Promyelocytic leukemia zinc finger controls type 2 immune responses in the lungs by regulating lineage commitment and the function of innate and adaptive immune cells. | 0 |
| 38442714 | 2024 | Human cortical neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression. | 2 |
| 38654107 | 2024 | ZBTB16 inhibits DNA replication and induces cell cycle arrest by targeting WDHD1 transcription in lung adenocarcinoma. | 0 |
| 38789960 | 2024 | Long non-coding RNA LINC00930 targeting miR-6792-3p/ZBTB16 regulates the proliferation and EMT of pancreatic cancer. | 1 |
| 38245954 | 2024 | Investigating the association of previously identified genome-wide significant loci (rs10739076 and rs1784692) with PCOS susceptibility and its related traits in Indian women. | 0 |
| 38287116 | 2024 | Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis. | 2 |
| 38373386 | 2024 | Promyelocytic leukemia zinc finger controls type 2 immune responses in the lungs by regulating lineage commitment and the function of innate and adaptive immune cells. | 0 |
| 38442714 | 2024 | Human cortical neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression. | 2 |
| 38654107 | 2024 | ZBTB16 inhibits DNA replication and induces cell cycle arrest by targeting WDHD1 transcription in lung adenocarcinoma. | 0 |
| 38789960 | 2024 | Long non-coding RNA LINC00930 targeting miR-6792-3p/ZBTB16 regulates the proliferation and EMT of pancreatic cancer. | 1 |
| 36216898 | 2023 | Hyperthermia promotes degradation of the acute promyelocytic leukemia driver oncoprotein ZBTB16/RARα. | 0 |
| 36768269 | 2023 | The Role of Promyelocytic Leukemia Zinc Finger (PLZF) and Glial-Derived Neurotrophic Factor Family Receptor Alpha 1 (GFRα1) in the Cryopreservation of Spermatogonia Stem Cells. | 1 |
| 36216898 | 2023 | Hyperthermia promotes degradation of the acute promyelocytic leukemia driver oncoprotein ZBTB16/RARα. | 0 |
Citation
Franck Viguié
ZBTB16 (zinc finger and BTB domain containing 16)
Atlas Genet Cytogenet Oncol Haematol. 1998-04-01
Online version: http://atlasgeneticsoncology.org/gene/37/zbtb16-(zinc-finger-and-btb-domain-containing-16)
