ALDH3A1 (aldehyde dehydrogenase 3 family member A1)

2004-05-01  

Identity

HGNC
ALDH3A1
LOCATION
17p11.2
LOCUSID
218
ALIAS
ALDH3,ALDHIII
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 218
MIM: 100660
HGNC: 405
Ensembl: ENSG00000108602

Variants:

dbSNP: 218
ClinVar: 218
TCGA: ENSG00000108602
COSMIC: ALDH3A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108602ENST00000225740P30838
ENSG00000108602ENST00000395555A8MYB8
ENSG00000108602ENST00000426645C9JKT2
ENSG00000108602ENST00000439102C9JMC5
ENSG00000108602ENST00000444455P30838
ENSG00000108602ENST00000457500P30838
ENSG00000108602ENST00000468746E9PNN6
ENSG00000108602ENST00000494157I3L3I9
ENSG00000108602ENST00000570414I3L3W9
ENSG00000108602ENST00000573368I3L4E5
ENSG00000108602ENST00000574162I3L1H6

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Histidine metabolismKEGGko00340
Tyrosine metabolismKEGGko00350
Phenylalanine metabolismKEGGko00360
beta-Alanine metabolismKEGGko00410
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glycolysis / GluconeogenesisKEGGhsa00010
Histidine metabolismKEGGhsa00340
Tyrosine metabolismKEGGhsa00350
Phenylalanine metabolismKEGGhsa00360
beta-Alanine metabolismKEGGhsa00410
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Metabolic pathwaysKEGGhsa01100
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD
PA449412doxorubicinChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
190256162008ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells.55
129435352003Human aldehyde dehydrogenase 3A1 (ALDH3A1): biochemical characterization and immunohistochemical localization in the cornea.53
184961312008Influence of polymorphisms of drug metabolizing enzymes (CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5, GSTA1, GSTP1, ALDH1A1 and ALDH3A1) on the pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide.44
127064982003Aldh3a1 protects human corneal epithelial cells from ultraviolet- and 4-hydroxy-2-nonenal-induced oxidative damage.34
159051742005Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells.27
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
247629602014Aldehyde dehydrogenase 3A1 associates with prostate tumorigenesis.24
190587892009A common variant in DRD3 receptor is associated with autism spectrum disorder.19
188547792008Relations between polymorphisms in drug-metabolising enzymes and toxicity of chemotherapy with cyclophosphamide, thiotepa and carboplatin.16

Citation

Dessen P

ALDH3A1 (aldehyde dehydrogenase 3 family member A1)

Atlas Genet Cytogenet Oncol Haematol. 2004-05-01

Online version: http://atlasgeneticsoncology.org/gene/374/aldh3a1-(aldehyde-dehydrogenase-3-family-member-a1)